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Front. Oncol. | doi: 10.3389/fonc.2019.00796

Novel associations within the tumor microenvironment: Fibulins meet ADAMTSs

Tania Fontanil1, Yamina Mohamedi2, Teresa Cobo3,  Santiago Cal4 and  Alvaro J. Obaya2*
  • 1Clínica Órdoñez, Spain
  • 2Universidad de Oviedo, Spain
  • 3Asturian Institute of Dentistry, University of Oviedo, Spain
  • 4Department of Biochemistry and Molecular Biology, University of Oviedo, Spain

The maintenance of tissue homeostasis in any organism is a very complex and delicate process in which numerous factors intervene. Cellular homeostasis not only depends on intrinsic factors but also relies on external factors that compose the microenvironment or cellular niche. Thus, extracellular matrix (ECM) components play a very important role in maintaining cell survival and behavior, and alterations in the ECM composition can lead to different pathologies. Fibulins and ADAMTS metalloproteases play crucial roles in the upkeep and function of the ECM in different tissues. In fact, members of both of these families of secreted multidomain proteins can interact with numerous other ECM components and thus shape or regulate the molecular environment. Individual members of both families have been implicated in tumor-related processes by exhibiting either pro- or antitumor properties. Recent studies have shown both an important relation among members of both families and their participation in several pathologies, including cardiogenesis or cancer. In this review, we summarize the associations among fibulins and ADAMTSs and the effects elicited by those interactions on cellular behavior.

Keywords: Fibulin, ADAMTS, microenvironment, versican, Aggrecan, Cellular migration and invasion

Received: 10 May 2019; Accepted: 06 Aug 2019.

Edited by:

Sergio Roa, Center of Applied Medical Research, School of Pharmacy and Nutrition, University of Navarra, Spain

Reviewed by:

Germain Gillet, Université Claude Bernard Lyon 1, France
Almudena Porras, Complutense University of Madrid, Spain  

Copyright: © 2019 Fontanil, Mohamedi, Cobo, Cal and Obaya. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Alvaro J. Obaya, Universidad de Oviedo, Oviedo, 33003, Asturias, Spain,