Impact Factor 4.137 | CiteScore 4.28
More on impact ›

Systematic Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.01290

Association between metabolic syndrome and breast cancer risk: an updated meta-analysis of follow-up studies

Meng Guo1, Tingting Liu2, Peiting Li3, Tianying Wang3, Chen Zeng3, Meng Yang3, Gang Li3, Jiang Han3,  Wei Wu3* and Ruopeng Zhang4*
  • 1Department of Surgery of Mammary Gland and Thyroid Gland, Jining First People's Hospital, China
  • 2Department of Breast Surgery, Tai'an City Central Hospital, China
  • 3Department of Breast Thyroid Surgery, Third Xiangya Hospital, Central South University, China
  • 4Department of Reproductive Medicine and Institute of Reproductive Medicine, First Affiliated Hospital, Dalian Medical University, China

Background: Association between metabolic syndrome (MetS) and incidence of breast cancer remains to be validated. Moreover, whether menopausal status of the women affects this association is unclear. A meta-analysis was performed to summarize the association between MetS and breast cancer risk.

Methods: Follow-up studies were identified by search of PubMed and Embase databases published until May 26, 2019. A random-effect model or fixed-effect model was applied to pool the results according to the heterogeneity. Subgroup analyses according to the menopausal status, ethnic groups, cancer histopathological features, and study design characteristics.

Results: Overall, seventeen follow-up studies with 602,195 women and 15,945 cases of breast cancer were included. Results of meta-analysis showed that MetS defined by the revised National Cholesterol Education Program’s Adults Treatment Panel III criteria was associated with significantly increased risk for breast cancer incidence (adjusted risk ratio [RR] = 1.15, p = 0.003). Subgroup analyses showed that MetS was associated with significantly increased risk of breast cancer in postmenopausal women (adjusted RR = 1.25, p < 0.001), but significantly reduced breast cancer risk in premenopausal women (adjusted RR = 0.82, p < 0.001). Further analyses showed that the association between MetS and increased risk of breast cancer were mainly evidenced from studies including Caucasian and Asian women, reporting invasive breast cancer, and of retrospective design.

Conclusions: Menopausal status may affect the association between MetS and breast cancer incidence. Postmenopausal women with Mets are associated with increased risk of breast cancer.

Keywords: metabolic syndrome, breast cancer, Postmenopausal, Meta-analysis, Incidence

Received: 12 Aug 2019; Accepted: 07 Nov 2019.

Copyright: © 2019 Guo, Liu, Li, Wang, Zeng, Yang, Li, Han, Wu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Wei Wu, Third Xiangya Hospital, Central South University, Department of Breast Thyroid Surgery, Changsha, 410013, Hunan Province, China, wwxy399_a@163.com
Dr. Ruopeng Zhang, First Affiliated Hospital, Dalian Medical University, Department of Reproductive Medicine and Institute of Reproductive Medicine, Dalian, China, zhangrp_92@yeah.net