Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

Background: Primary liver cancer is a leading cause of cancer deaths worldwide. Global burden varies, reflecting geographical distribution of viral hepatitis. Our objective was to perform a systematic review and meta-analysis of published current trends in incidence of adult liver cancers and histological types worldwide. Methods: This study used systematic searches of PubMed, Embase, CINAHL, and Web of Science databases for English-language peer-reviewed articles published from 1 January 2008 to 01 September 2019. Inclusion criteria were population-based studies of adult liver cancer patients with quantitative estimates of temporal trends in incidence for liver cancers and/or histological types. For multiple studies from the same geographical area, only the publication that reported the most recent trends for the same cancer type and population subgroup was included. Review was conducted per PRISMA guidelines. Two authors independently extracted data and critically assessed studies. Proposed contributors to observed trends were extracted from included articles. Study-specific estimates of the annual percentage change (APC) in incidence rates with 95% confidence intervals (CIs) were pooled using random-effects meta-analysis models. Heterogeneity was measured using the I2 statistics and publication bias evaluated using funnel plots and Egger's tests. Results: Overall, 53 studies met the inclusion criteria, of which 31 were included in the meta-analysis. Overall, pooled APC estimates were +0.8 (95% CI −0.3, +2.0) for liver cancers combined, +2.6 (95% CI +1.2, +4.0) for hepatocellular carcinoma (HCC), and +4.3 (95% CI +2.5, +6.1) for intrahepatic cholangiocarcinoma. Subgroup analyses indicated increasing trends for liver cancers (APC +3.2, 95% CI +2.5, +3.9) and HCC (APC +3.6, 95% CI +2.9, +4.4) in the region of North America/Europe/Australia, whereas corresponding trends were decreasing (APC −1.7, 95% CI −2.2, −1.1) and stable (APC −0.7, 95% CI −1.9, +0.5) in Asia, respectively. Conclusions: Incidence is increasing for adult liver cancers and HCC in Western countries, whereas trends are decreasing in the Asian region, although still remaining high. Our findings highlight the importance of viral hepatitis control and lifestyle interventions to reduce global liver cancer burden. Ongoing surveillance is also vital to detect early shifts in incidence trends.


Clinical Question
This review was conducted according to published PRISMA guidelines (13). The clinical question to guide the review was clearly defined following the structured PICOS framework and agreed upon before commencing the review process.
The PICOS question is: Among adults diagnosed with invasive liver cancer (Participants), was there any effect of calendar time (Intervention) from the start of the study time period (Comparisons) in the incidence rates (Outcomes) using population-based cohorts from cancer registries (Study design)?

Searches
The electronic databases PubMed, Embase, CINAHL, and Web of Science were systematically searched for all indexed articles from 1 January 2008 to focus on the most recent trends. Final searches were undertaken on 1 September 2019. Search strategies used selected subject headings and key words related to liver cancer, for example, "liver cancer, " "liver neoplasms, " "liver tumor, " "hepatocellular carcinoma, " "hepatic cancers, " "hepatic tumors, " and "intrahepatic cholangiocarcinoma, " combined with ("incidence" and "trends" and "epidemiology") (Supplementary File 1). Reference lists of reviews and retrieved articles were checked to identify potentially relevant articles.

Study Selection
Studies were eligible if they met the following predetermined selection criteria: 1) The study is population based.
2) The study cohort included adults aged at least 15 years diagnosed with liver cancer and/or subgroups. 3) Outcome measure was incidence rates. 4) Quantitative estimates of temporal trends in incidence rates were presented as percentage change over time.
The scope of the review was limited to English-language peerreviewed original research articles. Studies that only reported overall numbers or proportions of cases by time periods were excluded. Multiple studies from the same geographical area that used the same data collection were screened to avoid including duplicate data in the review. Only the publication that reported the most recent incidence trends for the same liver cancer type and population subgroup (such as sex, age group, and race/ethnicity) was included.
The titles and abstracts of all unique articles identified by the queries were independently reviewed for their eligibility by two reviewers (CH and PD). Discrepancies were discussed and resolved through consensus. The full text of all articles deemed potentially relevant and those whose abstracts and titles provided insufficient information were then retrieved for more detailed evaluation by the same two reviewers. These were categorized as "include" or "exclude" while noting the reasons for exclusion. All decisions were compared and discussed. If necessary, another author was consulted (PB).

Critical Appraisal
A modified (14) version of the Newcastle-Ottawa Scale (NOS) (15), a risk-of-bias assessment tool for nonrandomized studies, was used for quality assessment. Studies were scored according to the extent that they met each of the nine assessed criteria using an ordinal scale to rate the risk of bias as 0 (high), 1 (intermediate), and 2 (low). Individual item scores were then summed to give a total score. Finally, the summary score for each article (average of the total scores from the two reviewers) was categorized into "high" (14)(15)(16)(17)(18), "moderate" (9-13.5), or "low" (<9) quality. Studies were not excluded based specifically on their quality rating.

Data Extraction and Synthesis
For all included articles, one reviewer (CH) collected data on bibliography [author(s), year, and title], study characteristics (location, time period, design, sample size, population, and liver cancer type), relevant statistical findings for the entire cohort and/or by population subgroups, and methodological details. A second reviewer (PD) independently checked the data extract against the original source for all included articles.
Incidence was reported as age-standardized rates, with standardization being commonly performed to world or US standard populations. While trends were presented as either the annual percentage change (APC) or average APC (AAPC) over time; for simplicity, the term APC is used throughout this review for both trend measures.
Incidence trends are first presented for all liver cancers combined and then separately for each histological type. Studies are sorted by sex and age group and then by country within each of the continents (Africa, Americas, Asia, Europe, and Oceania). Some studies are repeated either in the same table or across multiple tables. Only the most recent trend is considered for studies that reported changing trends over time.
In describing trends, the terms "increase" for positive point estimates and "decrease" for negative values were used when the reported trend estimate (APC) was statistically significant (P < 0.05). Otherwise, if the 95% confidence interval (CI) included zero, the term "stable" was used. The term "short term" indicated that the time interval over which the trend was reported was <12 years, whereas "long term" describes trends over at least 12 years.

Data Analysis
The published trend estimates were pooled using randomeffects meta-analysis models (16) that allow for the inherent heterogeneity of observational studies. Only studies that also reported corresponding 95% CI for point estimates and sufficiently homogeneous in terms of cohort characteristics (such as age group) were retained for the meta-analysis. We also compared included vs. excluded studies by looking at the distribution of the APC point estimates and geographical location.
The pooled outcome measures were stratified by cancer type: combined liver cancers, HCC, and ICC with additional subgroup analyses by three regional categories, namely, Asia; North America/Europe/Australia comprising USA, Canada, Australia, and European countries; and Africa/South America (less developed; countries in Africa and South America), performed if there were at least four studies per stratum. Summary estimates by smaller age groups, ethnicity, or race were not generated due to wide variability in their definitions.
Heterogeneity between study-specific estimates was assessed with the Q and I 2 statistics (17). Publication bias was evaluated by funnel plots and Egger tests (18). Sensitivity analyses were conducted by assessing the impact on the summary measure of dropping specific studies. The influence of individual studies on the pooled estimates was assessed by repeating the meta-analysis, omitting one study at a time.
Forest plots were used for graphical presentation of metaanalysis results. All analyses were performed with Stata/SE version 15 (StataCorp, TX, USA).

Study Selection
As shown in a PRISMA diagram (Figure 1), a total of 700 articles were identified through the search queries, with an additional 26 records found through other sources. The removal of duplicates left 631 potentially eligible records, of which 455 were excluded after initial screening of the title and abstracts as they were not relevant to the study objectives. Of the remaining 176 fulltext articles that were evaluated for eligibility, 53 were retained for the review. The majority (n = 97) of the 123 excluded articles mentioned incidence trends in the abstract but did not specifically present quantitative estimates of these trends, while seven were based on analysis of estimated data from a secondary source and 19 articles were excluded to avoid duplication of data in the review (Supplementary File 2).

Location
Sixteen of the included studies were from the USA, followed by China (9), Australia (6), South Korea (3), Japan (3), Thailand (2), and the Netherlands (2). Three more studies were also from Europe (one each from Cyprus, France, and Spain) and Asia (one each from the Philippines, Taiwan, and Lebanon), two more from the Americas (Canada and Colombia), and four from Africa (one each from Botswana, Gambia, Mozambique, and Uganda).

Cohort
Data for all included studies were sourced from population-based state or nationwide cancer registries, with three also accessing other administrative databases.
The median cohort size was 10,170 [interquartile range (IQR): 789-34,695]. Of the 53 studies, 28 reported trends for all liver cancers, 15 for HCC only, 7 for ICC, 1 for both HCC and ICC, and 1 for all liver cancers and HCC. One study looked at combined HCC and cholangiocarcinoma (cHCC-CC), a rare type of primary liver cancer.
The definition of "adult" varied in the included studies, with most including all ages above at least 15 years, although some restricted the upper boundary to <80 years. Eleven of 53 studies reported additional age-specific trends. Around half (n = 28) reported incidence trends for persons, of which 15 also presented sex-specific estimates, while the remaining studies (n = 25) only reported trends by sex. The only studies that reported trends by race and/or ethnicity were from the USA (10 of 16 studies).

Outcome Measure
All studies reported trends for age-standardized incidence rates in terms of APCs. Sixteen studies standardized age to the 2000 US population, 10 to the 1960 Segi World population, 13 to the 2000 world population, six to the 2001 Australian population, two to the European population, and 1 each to the 1985 Japanese, 2010 Korean, and 1996 Canadian populations. Three studies did not specify the standard population.

Quality
Twenty-two studies were rated as high quality, and the remaining 31 as moderate ( Table 1, Supplementary Table 3.1). The median score was 13.5 (IQR: 13.0-14.0).

Meta-Analysis
Of the 53 studies, 31 (59%) were retained for the meta-analysis. Excluded studies did not present 95% CIs for the trend estimates (n = 16), only reported APCs by population subgroups (n = 5), or only reported on a rare liver cancer type (n = 1).

Liver Cancers Combined
Incidence trends varied by geographical region with 10 (four high quality and six moderate) of 11 included studies from North America/Europe/Australia reporting increasing trends and one (moderate quality) stable trends. In addition, of five studies from Africa/South America, three (moderate quality) described increasing trends, one (moderate quality) stable trends, and one (moderate quality) decreasing trends. By contrast, of 13 studies from Asia, 10 (two high quality and eight moderate) described decreasing incidence trends, two (one high quality and one moderate) stable trends, and one (moderate quality) increasing trends (Figure 2, Table 1, Supplementary Table 3

.2).
One study reported decreasing trends in Botswana (19) and another increasing incidence in Uganda (22) among persons until 2008. Moreover, rates remained stable over two decades to mid-2000s among males but increased among females in the Gambia (20), whereas corresponding trends were stable among both sexes in Mozambique (21).
In contrast, six Chinese studies reported decreasing liver cancer incidence rates among males, females, or persons over the past one to three decades (30)(31)(32)(33)(34)37) with two more (35,36) describing stable trends from around 2000. Two studies from Japan (38,39) and one from South Korea (40) also reported decreasing incidence across both sexes over recent decades, consistent with the decrease in the Philippines between 1983 and 2002 (42). However, sex-specific trends increased in Lebanon between 2003 and 2008 (41).

Trends by Age
Two studies from the USA reported that long-term trends increased over recent decades among adults ≥45 years (24,26), decreased among those aged 35-44 (24) or 40-44 (26), and remained stable among those younger ( Table 2). In contrast, incidence rates decreased across all age groups among persons aged 75 or younger over the past 10 years until around 2014 in China (31,37).

Hepatocellular Carcinoma
Of the 13 studies from non-Asian countries (all from North America/Europe/Australia), 11 (eight high quality and three moderate) reported increasing incidence rates, one (high quality) stable, and one (moderate quality) decreasing trends, whereas three (of four) studies from Asia (one high quality and two moderate) described stable and/or decreasing trends while one (high quality) noted an increase ( Figure 2, Table 1,  Supplementary Table 3

.3).
Five studies from the USA and one from Canada all reported increasing short-term (48) or long-term trends until the early 2000s (54) or later (49,50,52,53). This pattern was evident among persons (48,50,52,53) and/or by sex (49,(52)(53)(54) with only one study (48) noting increasing short-term incidence for males but a stable trend among females. In addition, one study described a short-term stable trend among persons from 2010 to 2015 in the USA (51). Incidence rates increased in males but were stable among females (and persons) over two decades until 2009 in the Netherlands (45). Two Australian studies also reported increasing long-term trends among both males and females until around 2013 (59, 63) although another found that incidence increased among males but remained stable in females from 1996 to 2011 (61).
In contrast, trends decreased among males but remained stable among females from 1974 to 2005 in China (55), were stable among persons (and by sex) in Taiwan from 2003 to 2011 (57), decreased among both males and females (<69 years, 1981-2003) in Japan (56), and were stable among males (2007-2013) while increasing among females  in Thailand (58).   Finally, while HCC incidence rates increased in Australia among the HBV-infected population from 1996 to 2010 in one study (60), corresponding trends were stable among those with HBV while decreasing among the HCV-infected population between 1992 and 2007 (62).

Trends by Age
Patterns for age-specific trends were mixed ( Table 2). There was a suggestion of increasing trends among older adults (≥60 years) in the USA (49-53), whereas they decreased (53) for persons aged 35-49 years and were stable for younger age groups (53) over at least 10 years from 2000 onwards. One study reported that incidence rates had decreased among both younger (40-49 years) and middle-aged (49-53, 55, 57, 59, 61, 63) adults since around mid-2000s to 2015 (51).
Age-specific rates increased by sex for those aged >50 years but only among younger males in Canada from 1976 to 2000 (54), while in the Netherlands, long-term trends (until 2009) increased among both males and females <60 years, whereas for those older, they increased among males but were stable for females (45). In contrast, rates decreased between 1981 and 2003 among both males and females <69 years of age in Japan but were stable among those aged 70-79 (56). In Taiwan, short-term trends decreased among persons <65 years but increased for those older between 2000 and 2003 (57). One Australian study described increasing long-term trends among persons aged at least 50 years (stable for ages 45-49) (63), whereas another reported increasing trends for males and stable trends for females across all age groups (61).

Intrahepatic Cholangiocarcinoma
Six (four high and two moderate quality) of the eight included studies reported increasing trends, and two (both moderate quality) found decreasing trends (Figure 2, Table 1,  Supplementary Table 3.4). All three studies from the USA (64-66) and one from the Netherlands (70) described increasing short-or long-term trends among persons over recent decades until at least the late 2000s. While sex-specific rates increased from 1999 to 2005 (68) in South Korea, another study from the same country reported decreasing trends among persons over the decade until 2015 (67). Similarly, one study from Thailand (58) reported increasing long-term trends among both males and females over two decades until 2013, and another reported decreasing trends from 2003 to 2009 (69).

Trends by Age
While long-term trends increased across all ages in the USA until 2013 (66), they were stable among all age groups except those aged 45-59 years, for whom they increased from 1989 to 2009 in the Netherlands (70) ( Table 2).

Summary Estimates
For ICC, the pooled estimate of +4.3 (95% CI +2.5, +6.1) from four retained studies indicated large increases in incidence trends. There was high (I 2 = 79.1%) and significant heterogeneity (Q = 19.1, P = 0.001) between the studies ( Figure 5); however, no evidence of publication bias was noted (Egger P = 0.68, Supplementary Figure 4.1). Trend patterns did not change during the sensitivity analysis. Summary estimates by region were not performed due to an insufficient number of studies.

Combined Hepatocellular Cholangiocarcinoma
One study reported an increase in the incidence of cHCC-CC among both males and females over recent decades until 2014 in the USA (71).

Trends by Race and/or Ethnicity (USA Only)
Two studies found increasing liver cancer rates overall for each analyzed racial/ethnic group (23,25) while another reported increasing trends among non-Hispanic Whites for  both sexes, whereas they decreased among Asian/Pacific Islander (API) men and were stable among API women (27) (Supplementary Table 3.5). Incidence trends over the most recent 5-year period (2011-2015) also increased among both males and females for six major racial and ethnic groups in the USA except Hispanic men and API women (both with stable trends) and API men (decreasing trends) (28). Two studies reported increasing HCC incidence across all considered racial/ethnic groups (49,50), and two others found increasing trends for all groups (52,53) except APIs, where trends were either stable (52) or decreasing (53). Age-specific HCC incidence rates also increased from 1992 to 2015 among persons 60 years and older in all racial/ethnic groups except APIs aged 70-79 years, whereas they decreased among ages 40-59 years of all races/ethnicities since the mid-2000s (51). Long-term trends for ICC increased across all racial/ethnic groups until 2013 (66).

Comparison of Excluded and Included Studies in Meta-Analysis
Visual inspection of box-and-whiskers plots for trend estimates from included and excluded studies in the meta-analysis (Supplementary Figure 4.2) showed that the median APC point estimate across studies excluded from the meta-analysis for liver cancers combined was skewed toward the right (lower or negative trends). However, the spread of the data was comparable between these two groups. For HCC and ICC, the median for the included and excluded studies was positive. Moreover, for all liver cancers (but not the two subtypes), a greater percentage of studies from the Asian region was excluded compared to non-Asian studies (62 vs. 38%, respectively-see Supplementary Figure 4.3).

Summary of Main Findings
Our comprehensive systematic review found that the incidence rates for adult liver cancers combined and for HCC, the most commonly diagnosed histological subtype (4), continue to increase in Western countries. In contrast, trends decreased or were stable over recent decades for several Asian countries. These geographical patterns were reflected in summary pooled estimates from random-effects meta-analysis (16), which indicated that while trends were increasing overall and in Western countries (North America/Europe/Australia region) for both combined liver cancer and HCC, corresponding rates decreased or were stable in Asia, respectively. The different patterns may reflect geographical variation in the ratio of liver cancers attributable to HBV and HCV, with HBV being the leading etiology in Asia, whereas the opposite is true in the USA and other Western countries (8), hence the decrease of newly diagnosed HCC cases following the implementation of mass HBV immunization in countries like China and South Korea. Our results highlight the substantial variation in liver cancer incidence across countries and the need for ongoing monitoring of patterns for population subgroups within regions.
We found that incidence rates for ICC, which comprises 12-15% of all liver cancer cases (4), have increased over recent decades. Summary estimates were also suggestive of rapidly increasing trends for ICC. ICC remains, in large part, a clinical diagnosis (72), so increases in incidence rates of this cancer may reflect improved diagnostic techniques (72) and greater awareness among clinicians. This is especially so in Southeast Asian countries where ICC is endemic due to liver fluke infections (9,10). However, recognized risk factors for ICC only account for approximately half of diagnosed cases in Western countries (10); hence, it is possible that as yet unknown etiological risk factors may also be involved.
No publication bias was detected for any of the reported meta-analysis. Sensitivity analysis suggested that the presented summary estimates are unlikely to be chance findings. Pooled estimates need to be interpreted with some caution, however, given the different periods and cohort characteristics of the included studies.

Geographical Burden of Liver Cancer
Despite the temporal increase in liver cancer incidence in Western countries, incidence rates in Asian countries remain among the highest in the world (1). In 2018, around a quarter of all incident cases and deaths occurred in Asia, with China alone accounting for around half of the global burden (5). In addition, age-standardized rates among males and females in China were around three times higher than corresponding rates in the USA (males 27.6 vs. 10.4 per 100,000; females 9.0 vs. 3.4 per 100,000). These rates largely reflect the geographical variations in the prevalence of HBV infections, which have been estimated to be around 18% in China (73) compared to <1% in the USA (74). Hence although declining liver cancer incidence trends in Asia are a positive development, they remain a major contributor to the global liver cancer burden. In addition, the high liver cancer mortality rate (1) translates to a heavy burden on health systems that may not have resources required for intensive surgical and clinical management of HCC (7,75).

Proposed Drivers of Incidence Trends
Viral hepatitis infections are the key driving etiology of liver cancers, especially HCC (8). High prevalence of chronic HBV among immigrants to Western countries from endemic HBV regions such as Asia (8) was widely proposed as a contributor to increasing incidence trends (23, 27, 28, 47, 49, 52-54, 59-61, 63, 64). In the West, current increases in incidence also stem from a clinical lag time from HCV infection epidemics of the 1970s and 1980s, with these individuals now evolving to liver cirrhosis with the associated higher HCC risk (23-28, 44, 45, 47, 49, 51-54, 59, 61, 63-65). Reducing exposures to these risk factors is logically the most effective way to lower the risk of developing liver cancer, and this was reflected in the most commonly cited reasons for decreasing incidence rates being mass HBV immunization (30-34, 37, 42, 55, 57, 67), controlling HCV transmission (30,39,51,56), and efficacy of antiviral therapies for hepatitis infection (19, 27, 37-39, 56, 57, 62). New anti-HCV treatments widely available in Western countries offer effective cure of HCV even for patients with advanced liver disease and reduce HCC risk by ∼70% (76); however, their potential benefit has been hampered by lack of affordability and insurance coverage among certain population subgroups (73,75,77).
Several key risk factors for liver cancers are modifiable (7), including obesity, excessive alcohol use, smoking, and viral hepatitis infections, reflected in 71% of cases in the USA (11) being estimated to be potentially preventable. Many of the included studies highlighted the importance of continuing efforts to reduce the risks associated with viral hepatitis through primary (HBV vaccination) (23,25,27,48,49,60) and secondary prevention efforts. The latter include screening of high-risk populations (23,31,47,49,(51)(52)(53)61) and ensuring equitable access to curative therapies for HBV/HCV infections among all population subgroups (23,32,37,47,48,52,53,59). However, even if incidence of HCV-related HCC decreases in the future due to improved treatments and better control (75,81), this may be offset by the emerging etiological importance of NAFLD as a key risk factor (77,82). The latter reflects the continuing increase in the global prevalence of obesity (83,84) and diabetes (84,85), two well-established risk factors for NAFLD (86). Hence, targeted strategies for promoting healthier lifestyles (20, 23, 25, 27, 33, 36, 37, 47, 51-53, 59, 66) are also vital for reducing the global liver cancer burden. The challenge is in the development and implementation of successful strategies to achieve this goal (7,75,77,87), which is especially important given the high mortality rates (1) and poor survival for liver cancer (88).
The consistently high and increasing liver cancer, and in particular HCC, incidence rates among middle-aged adults in the USA (24,26,49,(51)(52)(53) reflect the birth cohort effect related to HCV infection which peaked among Americans born between 1945 and 1965 through intravenous drug use during the 1960s−1980s (89). While not the primary focus of this review, racial and ethnic variations in liver cancer incidence rates in the USA were attributed at least partially to differences in the distribution of major risk factors and protective practices related to viral hepatitis control among different groups and over time (25,27,50,53). For example, although APIs in the USA have had historically high liver cancer/HCC incidence rates, reflecting endemic HBV infectious among Asians, greater awareness and uptake of viral hepatitis screening and antiviral therapy may have contributed to generally decreasing trends since the mid-2000s (27,(51)(52)(53).

Limitations
Limitations included high heterogeneity between the retained studies for the meta-analyses and the underrepresentation of studies from high-incidence countries in Africa and Asia (except Eastern and Southeastern Asia). Notably, of 31 studies included in the calculation of the pooled estimates, only three (Mozambique, Gambia, and Uganda) were from developing countries as defined by the 2019 HDI classification (12).
Although multiple databases were searched with complex queries and reference lists of identified articles were also used to maximize the completeness of those included, we acknowledge that the search terms and criteria used as well as choice of citation databases could have unintentionally resulted in some relevant articles being excluded. Only peer-reviewed published studies in English were included; hence, this review could potentially be subject to language bias.
Wide temporal and demographical variability across included studies could have impacted between-study heterogeneity. Geographical variations in the availability of high-quality cancer registry data, which could influence the reported incidence trends, mean that comparisons between (and even within) countries must be interpreted cautiously (90). Another potential limitation is the differing standard populations used for generating the ASRs.
Around two-thirds (n = 31, 59%) of the 53 included studies were retained in the meta-analysis; however, comparison of the point trend estimates and geographical location between the included and excluded studies suggested that the former group was broadly representative of all reviewed studies. It is nonetheless possible that the summary trend estimates may have been overestimated given that estimates from the excluded studies tended to have a right-skewed distribution in comparison to the included studies. In addition, the limited information on plausible contributors in population-based cancer registries restricted the ability of the study authors to draw firm conclusions regarding the true drivers of the reported trends.

CONCLUSIONS
This review summarizes published estimates of global incidence trends in combined adult liver cancers by key histological types. In general, a continuing increase in incidence rates, especially among middle-aged adults, was evident across recent decades in several Western countries with historically low incidence rates. However, while trends decreased in several Asian countries, they still have the highest incidence rates worldwide, and absolute numbers remain very high. These findings highlight that liver cancer is likely to remain a major public health problem in the coming decades, albeit with a change in the distribution of cases worldwide. Demographic transition in countries where HBV is endemic offers significant hope to eventually curb the high mortality burden of HCC, though improvement is unlikely to be imminent. Emerging global trends in obesity and metabolic risk factors suggest that a new risk horizon for HCC is now evident in the West and looming in Asian and developing countries. Our findings also highlighted the impact of various public health strategies in reducing the incidence trends of viral hepatitis-related liver cancer. Design and implementation of evidence-based programs to reduce the global liver cancer burden, for example, through viral hepatitis control and lifestyle interventions, are a priority. Ongoing epidemiological surveillance is also vital to detect early shifts in incidence trends, particularly within high-risk population groups.

DATA AVAILABILITY STATEMENT
The raw data used in the meta analyses included in this article will be made available by the authors upon request.

AUTHOR CONTRIBUTIONS
PB, PD, JA, and DY contributed to the design of the study. PB and PD coordinated the study. PD and CH conducted the literature searches and acted as reviewers. PD drafted the manuscript. PB contributed to the initial draft of the manuscript. PB, PD, DY, JA, PC, and CH refined and approved the final version of the paper. Each author has participated sufficiently in the work and takes responsibility for appropriate portions of the content. All authors have read and have given final approval of the version to be published.