@ARTICLE{10.3389/fonc.2020.01506, AUTHOR={Miran, Isabelle and Scherer, Dominique and Ostyn, Pauline and Mazouni, Chafika and Drusch, Françoise and Bernard, Marine and Louvet, Emilie and Adam, Julien and Mathieu, Marie-Christine and Haffa, Mariam and Antignac, Jean-Philippe and Le Bizec, Bruno and Vielh, Philippe and Dessen, Philippe and Perdry, Hervé and Delaloge, Suzette and Feunteun, Jean}, TITLE={Adipose Tissue Properties in Tumor-Bearing Breasts}, JOURNAL={Frontiers in Oncology}, VOLUME={10}, YEAR={2020}, URL={https://www.frontiersin.org/articles/10.3389/fonc.2020.01506}, DOI={10.3389/fonc.2020.01506}, ISSN={2234-943X}, ABSTRACT={The tissue stroma plays a major role in tumors' natural history. Most programs for tumor progression are not activated as cell-autonomous processes but under the conditions of cross-talks between tumor and stroma. Adipose tissue is a major component of breast stroma. This study compares adipose tissues in tumor-bearing breasts to those in tumor-free breasts with the intention of defining a signature that could translate into markers of cancer risk. In tumor-bearing breasts, we sampled adipose tissues adjacent to, or distant from the tumor. Parameters studied included: adipocytes size and density, immune cell infiltration, vascularization, secretome and gene expression. Adipose tissues from tumor-bearing breasts, whether adjacent to or distant from the tumor, do not differ from each other by any of these parameters. By contrast, adipose tissues from tumor-bearing breasts have the capacity to secrete twice as much interleukin 8 (IL-8) than those from tumor-free breasts and differentially express a set of 137 genes of which a significant fraction belongs to inflammation, integrin and wnt signaling pathways. These observations show that adipose tissues from tumor-bearing breasts have a distinct physiological status from those from tumor-free breasts. We propose that this constitutive status contributes as a non-cell autonomous process to determine permissiveness for tumor growth.} }