AUTHOR=Wang Jiaqiang, Cheng Chien-shan, Lu Yan, Sun Shen, Huang Shaoqiang TITLE=Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling JOURNAL=Frontiers in Oncology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/articles/10.3389/fonc.2021.610514 DOI=10.3389/fonc.2021.610514 ISSN=2234-943X ABSTRACT=Volatile anesthetics are widely used inhalation anesthetics in clinical anesthesia. In recent years, the regulation of anti-cancer relevant signaling of volatile anesthetics has drawn the attention of investigators. However, their underlying mechanism remains unclear. This review summarizes the research progress on the regulation of anti-cancer relevant signaling of volatile anesthetics, including sevoflurane, desflurane, xenon, isoflurane, and halothane in vitro, in vivo, and clinical studies. The present review article aims to provide a general overview of regulation of anti-cancer relevant signaling and explore potential underlying molecular mechanisms of volatile anesthetics. It may promote promising insights of guiding clinical anesthesia procedure and instructing enhance recovery after surgery (ERAS) with latent benefits.