TY - JOUR AU - Spolverato, Gaya AU - Capelli, Giulia AU - Battagello, Jessica AU - Barina, Andrea AU - Nordio, Susi AU - Finotti, Elena AU - Mondi, Isabella AU - Da Lio, Corrado AU - Morpurgo, Emilio AU - Navarro, Josè Adolfo AU - Ceccato, Fabio AU - Perin, Alessandro AU - Pedrazzani, Corrado AU - Turri, Giulia AU - Zanus, Giacomo AU - Campi, Michela AU - Massani, Marco AU - Di Giacomo, Adriana AU - Prando, Daniela AU - Agresta, Ferdinando AU - Pucciarelli, Salvatore AU - Zorzi, Manuel AU - Rugge, Massimo PY - 2021 M3 - Original Research TI - More Favorable Short and Long-Term Outcomes for Screen-Detected Colorectal Cancer Patients JO - Frontiers in Oncology UR - https://www.frontiersin.org/articles/10.3389/fonc.2021.620644 VL - 11 SN - 2234-943X N2 - BackgroundScreening significantly reduces mortality from colorectal cancer (CRC). Screen detected (SD) tumors associate with better prognosis, even at later stage, compared to non-screen detected (NSD) tumors. We aimed to evaluate the association between diagnostic modality (SD vs. NSD) and short- and long-term outcomes of patients undergoing surgery for CRC.Materials and MethodsThis retrospective cohort study involved patients aged 50–69 years, residing in Veneto, Italy, who underwent curative-intent surgery for CRC between 2006 and 2018. The clinical multi-institutional dataset was linked with the screening dataset in order to define diagnostic modality (SD vs. NSD). Short- and long-term outcomes were compared between the two groups.ResultsOf 1,360 patients included, 464 were SD (34.1%) and 896 NSD (65.9%). Patients with a SD CRC were more likely to have less comorbidities (p = 0.013), lower ASA score (p = 0.001), tumors located in the proximal colon (p = 0.0018) and earlier stage at diagnosis (p < 0.0001). NSD patients were found to have more aggressive disease at diagnosis, higher complication rate and higher readmission rate due to surgical complications (all p < 0.05). NSD patients had a significantly lower Disease Free Survival and Overall Survival (all p < 0.0001), even after adjusting by demographic, clinic-pathological, tumor, and treatment characteristics.ConclusionsSD tumors were associated with better long-term outcomes, even after multiple adjustments. Our results confirm the advantages for the target population to participate in the screening programs and comply with their therapeutic pathways. ER -