AUTHOR=Pharaon Rebecca R. , Xing Yan , Agulnik Mark , Villaflor Victoria M. 

TITLE=The Role of Immunotherapy to Overcome Resistance in Viral-Associated Head and Neck Cancer

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.649963

DOI=10.3389/fonc.2021.649963

ISSN=2234-943X

ABSTRACT=<p>A subset of head and neck cancers arising in the oropharynx and the nasopharynx are associated with human papillomavirus or Epstein–Barr virus. Unfortunately, limited treatment options exist once patients develop recurrent or metastatic disease in these cancers. Interest has risen in utilizing novel strategies including combination immune checkpoint inhibitors, vaccines, and adoptive cellular therapy, to improve treatment response and outcomes. Several ongoing studies are investigating the potential to overcome resistance to standard of care chemoradiation therapy with monotherapy or combination immunotherapy strategies in these viral-associated head and neck cancers.</p>