AUTHOR=De Martino Mara , Padilla Oscar , Daviaud Camille , Wu Cheng-Chia , Gartrell Robyn D. , Vanpouille-Box Claire TITLE=Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma JOURNAL=Frontiers in Oncology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.671044 DOI=10.3389/fonc.2021.671044 ISSN=2234-943X ABSTRACT=

Glioblastoma (GBM) is among the most aggressive of brain tumors and confers a dismal prognosis despite advances in surgical technique, radiation delivery methods, chemotherapy, and tumor-treating fields. While immunotherapy (IT) has improved the care of several adult cancers with previously dismal prognoses, monotherapy with IT in GBM has shown minimal response in first recurrence. Recent discoveries in lymphatics and evaluation of blood brain barrier offer insight to improve the use of ITs and determine the best combinations of therapies, including radiation. We highlight important features of the tumor immune microenvironment in GBM and potential for combining radiation and immunotherapy to improve prognosis in this devastating disease.