TY - JOUR AU - Ofek-Shlomai, Noa AU - Berger, Itai PY - 2014 M3 - Mini Review TI - Inflammatory Injury to the Neonatal Brain – What Can We Do? JO - Frontiers in Pediatrics UR - https://www.frontiersin.org/articles/10.3389/fped.2014.00030 VL - 2 SN - 2296-2360 N2 - Perinatal brain damage is one of the leading causes of life long disability. This damage could be hypoxic–ischemic, inflammatory, or both. This mini-review discusses different interventions aiming at minimizing inflammatory processes in the neonatal brain, both before and after insult. Current options of anti-inflammatory measures for neonates remain quite limited. We describe current anti-inflammatory intervention strategies such as avoiding perinatal infection and inflammation, and reducing exposure to inflammatory processes. We describe the known effects of anti-inflammatory drugs such as steroids, antibiotics, and indomethacin, and the possible anti-inflammatory role of other substances such as IL-1 receptor antagonists, erythropoietin, caffeine, estradiol, insulin-like growth factor, and melatonin as well as endogenous protectors, and genetic regulation of inflammation. If successful, these may decrease mortality and long-term morbidity among term and pre-term infants. ER -