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This article is part of the Research Topic

Sepsis in Neonates and Children

Perspective ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pediatr. | doi: 10.3389/fped.2018.00425

Sepsis: Changing definitions, unchanging treatment

 Nchafatso G. Obonyo1, 2, 3, 4*,  Luregn J. Schlapbach2, 5, 6, 7 and John F. Fraser2, 7, 8
  • 1KEMRI Wellcome Trust Research Programme, Kenya
  • 2Critical Care Research Group (CCRG), Australia
  • 3Wellcome Trust Centre for Global Health Research, Imperial College London, United Kingdom
  • 4Initiative to Develop African Research Leaders (IDeAL), Kenya
  • 5Paediatric Intensive Care Unit, Lady Cilento Children’s Hospital, Australia
  • 6Abteilung für Pädiatrie, Inselspital Universitätsklinikum Bern, Switzerland
  • 7Faculty of Medicine, The University of Queensland, Australia
  • 8School of Medicine, Griffith Health, Griffith University, Australia

The recently revised Sepsis-3 definitions were based on criteria that were derived and validated in adult patient databases from high income countries. Both sepsis and septic shock continue to account for a substantial proportion of mortality globally, especially amongst children in low-and-middle income country settings. It is therefore urgent to develop and validate standardised criteria for sepsis that can be applied to paediatric populations in different settings, including in- and outside intensive care, both in high- and low/middle- income countries. This will be a pre-requisite to evaluate the impact of sepsis treatment strategies to improve clinical outcomes.

Keywords: Sepsis, septic shock, definitions, Paediatric populations, treatment bundles

Received: 04 Oct 2018; Accepted: 21 Dec 2018.

Edited by:

Jan Hau Lee, KK Women's and Children's Hospital, Singapore

Reviewed by:

OGUZ DURSUN, Akdeniz University, Turkey
Arun Bansal, Post Graduate Institute of Medical Education and Research (PGIMER), India  

Copyright: © 2018 Obonyo, Schlapbach and Fraser. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Nchafatso G. Obonyo, KEMRI Wellcome Trust Research Programme, Kilifi, Kenya,