%A Wang,Bo %A Wang,Li-nong %A Cheng,Fang-fang %A Lv,Hai-tao %A Sun,Ling %A Wei,Dong-kai %A Pu,Yu %A Wu,Jie %A Hou,Yuan-yuan %A Wen,Bin %A Xu,Xia-ping %A Yan,Wen-hua %D 2019 %J Frontiers in Pediatrics %C %F %G English %K kawasaki disease,other febrile illness,miRNAs,platelets,miR-222-3p %Q %R 10.3389/fped.2019.00237 %W %L %M %P %7 %8 2019-June-28 %9 Original Research %# %! miR-222-3p as diagnostic biomarker for Kawasaki disease %* %< %T MiR-222-3p in Platelets Serves as a Distinguishing Marker for Early Recognition of Kawasaki Disease %U https://www.frontiersin.org/articles/10.3389/fped.2019.00237 %V 7 %0 JOURNAL ARTICLE %@ 2296-2360 %X Kawasaki disease (KD) is an acute vasculitis, which leads to 20% of sufferers developing coronary artery aneurysm in children if not appropriately treated. Therefore, the early diagnosis of KD is essential for alleviating the risk of developing heart disease. MicroRNAs (miRNAs) are a large class of small non-coding RNAs which post-transcriptionally regulate gene expression and have been shown to play critical roles in numerous biological processes and diseases. In this study, we used high-throughput miRNA sequencing and found dozens of miRNAs are highly expressed in platelets. By comparing the miRNA expression profile of platelets of acute KD patients and other febrile patients, miR-222-3p is validated to be significantly upregulated in platelets of acute KD patients. Furthermore, KEGG pathway analysis shows that targets of miR-222-3p are enriched in immune-related signaling pathways. Our study uncovers the potential of miR-222-3p in platelets as biomarker for early diagnosis of Kawasaki disease.