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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pediatr. | doi: 10.3389/fped.2019.00481

Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID)

  • 1Ulm University Medical Center, Germany
  • 2CHU Sainte-Justine, Canada

Severe Combined Immunodeficiencies (SCID) are a heterogeneous group of monogenetic diseases. We describe the typical clinical presentation of patients with SCID as well as basic principles in diagnosis and therapy by hematopoietic stem cell transplantation. Therapeutic strategies may differ between subtypes and the inherently reduced capacity or inablility to reject a graft have to be considered.

Keywords: SCID, HSCT, conditioning, Engraftment, immune reconsitition, Clinical presentation, definition, Genetic subtypes

Received: 26 Sep 2019; Accepted: 01 Nov 2019.

Copyright: © 2019 Hoenig and Haddad. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: MD. Manfred Hoenig, Ulm University Medical Center, Ulm, Germany, manfred.hoenig@uniklinik-ulm.de