AUTHOR=Piacentini Roberto , De Chiara Giovanna , Li Puma Domenica D. , Ripoli Cristian , Marcocci Maria E. , Garaci Enrico , Palamara Anna T. , Grassi Claudio TITLE=HSV-1 and Alzheimer’s disease: more than a hypothesis JOURNAL=Frontiers in Pharmacology VOLUME=5 YEAR=2014 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2014.00097 DOI=10.3389/fphar.2014.00097 ISSN=1663-9812 ABSTRACT=

Among the multiple factors concurring to Alzheimer’s disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.