AUTHOR=Lemercier Clément E. , Schulz Steffen B. , Heidmann Karin E. , Kovács Richard , Gerevich Zoltan TITLE=Dopamine D3 Receptors Inhibit Hippocampal Gamma Oscillations by Disturbing CA3 Pyramidal Cell Firing Synchrony JOURNAL=Frontiers in Pharmacology VOLUME=6 YEAR=2016 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2015.00297 DOI=10.3389/fphar.2015.00297 ISSN=1663-9812 ABSTRACT=
Cortical gamma oscillations are associated with cognitive processes and are altered in several neuropsychiatric conditions such as schizophrenia and Alzheimer’s disease. Since dopamine D3 receptors are possible targets in treatment of these conditions, it is of great importance to understand their role in modulation of gamma oscillations. The effect of D3 receptors on gamma oscillations and the underlying cellular mechanisms were investigated by extracellular local field potential and simultaneous intracellular sharp micro-electrode recordings in the CA3 region of the hippocampus