AUTHOR=Lin Chun-Jung , Liao Wei-Chih , Chen Yu-An , Lin Hwai-Jeng , Feng Chun-Lung , Lin Cheng-Li , Lin Ying-Ju , Kao Min-Chuan , Huang Mei-Zi , Lai Chih-Ho , Kao Chia-Hung TITLE=Statin Therapy Is Associated with Reduced Risk of Peptic Ulcer Disease in the Taiwanese Population JOURNAL=Frontiers in Pharmacology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00210 DOI=10.3389/fphar.2017.00210 ISSN=1663-9812 ABSTRACT=
Although statin use may affect the severity of chronic gastritis and gastric cancer, no data exists about the relationship between statin therapy and risk of peptic ulcer disease (PUD) in patients. We investigated the effect of statin use and the incidence of PUD from the Taiwan National Health Insurance Research Database (NHIRD). A total of 35,194 patients records for medical claims were enrolled. We performed a population-based case-control analysis to compare the incidence of PUD in patients who were prescribed statins and that in patients who were not. In the univariate logistic analysis, we found that statin was not significant risk of PUD. However, a multivariate model indicates that satin use was significantly associated with a reduced risk of PUD (adjusted odds ratio [aOR] = 0.87, 95% CI = 0.82–0.93,