@ARTICLE{10.3389/fphar.2017.00221, AUTHOR={Lv, Xinrui and Kong, Jing and Chen, Wei-Dong and Wang, Yan-Dong}, TITLE={The Role of the Apelin/APJ System in the Regulation of Liver Disease}, JOURNAL={Frontiers in Pharmacology}, VOLUME={8}, YEAR={2017}, URL={https://www.frontiersin.org/articles/10.3389/fphar.2017.00221}, DOI={10.3389/fphar.2017.00221}, ISSN={1663-9812}, ABSTRACT={Apelin is an endogenous peptide that is a ligand for the APJ receptor (angiotensin II receptor like-1, AT-1). The apelin/APJ system is distributed in diverse periphery organ tissues. It has been shown that the apelin/APJ system plays various roles in physiology and pathophysiology of many organs. It regulates cardiovascular development or cardiac disease, glycometabolism and fat metabolism as well as metabolic disease. The apelin/APJ system participates in various cell activities such as proliferation, migration, apoptosis or inflammation. However, apelin/APJ function in the liver is still under investigation. In the liver, the apelin-APJ system could play an inhibitory role in liver regeneration and promote Fas-induced apoptosis. It may participate in the formation of hepatic fibrosis or cirrhosis, and even cancer. In this review, we summarize the role of the apelin/APJ system in liver disease.} }