%A Lv,Xinrui %A Kong,Jing %A Chen,Wei-Dong %A Wang,Yan-Dong %D 2017 %J Frontiers in Pharmacology %C %F %G English %K APJ,Liver disease,peptide,angiotensin II receptor like-1,Apelin %Q %R 10.3389/fphar.2017.00221 %W %L %M %P %7 %8 2017-April-24 %9 Mini Review %+ Wei-Dong Chen,Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, School of Medicine, Henan University,Kaifeng, China,ydwangbuct2009@163.com %+ Wei-Dong Chen,Key Laboratory of Molecular Pathology, School of Basic Medical Science, Inner Mongolia Medical University,Hohhot, China,ydwangbuct2009@163.com %+ Yan-Dong Wang,State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology,Beijing, China,ydwangbuct2009@163.com %# %! The role of apelin in liver %* %< %T The Role of the Apelin/APJ System in the Regulation of Liver Disease %U https://www.frontiersin.org/articles/10.3389/fphar.2017.00221 %V 8 %0 JOURNAL ARTICLE %@ 1663-9812 %X Apelin is an endogenous peptide that is a ligand for the APJ receptor (angiotensin II receptor like-1, AT-1). The apelin/APJ system is distributed in diverse periphery organ tissues. It has been shown that the apelin/APJ system plays various roles in physiology and pathophysiology of many organs. It regulates cardiovascular development or cardiac disease, glycometabolism and fat metabolism as well as metabolic disease. The apelin/APJ system participates in various cell activities such as proliferation, migration, apoptosis or inflammation. However, apelin/APJ function in the liver is still under investigation. In the liver, the apelin-APJ system could play an inhibitory role in liver regeneration and promote Fas-induced apoptosis. It may participate in the formation of hepatic fibrosis or cirrhosis, and even cancer. In this review, we summarize the role of the apelin/APJ system in liver disease.