TY - JOUR AU - Long, Wenyong AU - Yi, Yang AU - Chen, Shen AU - Cao, Qi AU - Zhao, Wei AU - Liu, Qing PY - 2017 M3 - Review TI - Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma JO - Frontiers in Pharmacology UR - https://www.frontiersin.org/articles/10.3389/fphar.2017.00495 VL - 8 SN - 1663-9812 N2 - Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effective treatments. This article reviews the conventional therapies and new potential therapeutic approaches for DIPG, including epigenetic therapy, immunotherapy, and the combination of stem cells with nanoparticle delivery systems. ER -