%A Zhong,Zhang-Feng %A Yu,Hai-Bing %A Wang,Chun-Ming %A Qiang,Wen-An %A Wang,Sheng-Peng %A Zhang,Jin-Ming %A Yu,Hua %A Cui,Liao %A Wu,Tie %A Li,De-Qiang %A Wang,Yi-Tao %D 2017 %J Frontiers in Pharmacology %C %F %G English %K Furanodiene,multidrug resistance,breast cancer,cell apoptosis,Intrinsic/extrinsic apoptosis,NF-κB %Q %R 10.3389/fphar.2017.00648 %W %L %M %P %7 %8 2017-September-14 %9 Original Research %+ Zhang-Feng Zhong,Guangdong Key Laboratory for Research and Development of Natural Drugs, School of Public Health, Guangdong Medical University,Zhanjiang, China,ytwang@umac.mo %+ Zhang-Feng Zhong,State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau,Macao, China,ytwang@umac.mo %+ De-Qiang Li,Department of Pharmacy, The Second Hospital of Hebei Medical University,Shijiazhuang, China,ytwang@umac.mo %+ Yi-Tao Wang,State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau,Macao, China,ytwang@umac.mo %# %! Furanodiene induces multidrug resisant cancer cell apoptosis %* %< %T Furanodiene Induces Extrinsic and Intrinsic Apoptosis in Doxorubicin-Resistant MCF-7 Breast Cancer Cells via NF-κB-Independent Mechanism %U https://www.frontiersin.org/articles/10.3389/fphar.2017.00648 %V 8 %0 JOURNAL ARTICLE %@ 1663-9812 %X Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae. Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear. Our study found that furanodiene could display anti-cancer effects by inhibiting cell viability, inducing cell cytotoxicity, and suppressing cell proliferation in doxorubicin-resistant MCF-7 breast cancer cells. Furthermore, furanodiene preferentially causes apoptosis by interfering with intrinsic/extrinsic-dependent and NF-κB-independent pathways in doxorubicin-resistant MCF-7 cells. These observations also prompt that furanodiene may be developed as a promising natural product for multidrug-resistant cancer therapy in the future.