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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2018.01363

Value of Contrast-enhanced Ultrasound and Acoustic Radiation Force Impulse Imaging for the Differential Diagnosis of Benign and Malignant Thyroid Nodules

 YAN HE1,  XIAO YAN WANG1*,  QIAO HU1*, XUE XUE CHEN1, BING LING1 and HAI MING WEI1
  • 1People's Hospital of Guangxi Zhuang Autonomous Region, China

Objectives: To assess the value of contrast-enhanced ultrasound (CEUS) and acoustic radiation force impulse (ARFI) imaging for the differential diagnosis of benign and malignant thyroid nodules.
Methods: CEUS was performed in eighty-eight thyroid nodules. The patterns of CEUS were analyzed, and the ARFI technique was then performed. The shear wave velocities (SWVs) of the nodules and the surrounding normal thyroid tissue were obtained. The areas under the curve (AUCs) and cut-off points were obtained by using a receiver operating characteristic (ROC) curve analysis. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic rate of each modality were assessed and compared using pathological diagnosis.
Results: Among 88 nodules, 29 nodules were malignant and 59 were benign. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic rate of CEUS were 79.3%, 91.5%, 82.1%, 90% and 87.5%, respectively. Using a cut-off value of 2.565 m/s for SWV, the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic rate for malignancy were 75.9%, 94.9%, 88.0%, 88.9% and 88.6%, respectively. The AUC was 0.878. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic rate of CEUS in combination with ARFI were 93.1%, 89.8%, 81.8%, 96.3% and 90.9%, respectively.
Conclusions: Both CEUS and ARFI are valuable for the differential diagnosis of benign and malignant thyroid nodules. Combining these two methods can improve the diagnostic rate.

Keywords: Thyroid Nodule, contrast-enhanced ultrasound, acoustic radiation force impulse-imaging, shear wave velocity, receiver operating characteristic curve

Received: 05 Sep 2018; Accepted: 05 Nov 2018.

Edited by:

Fei Yan, Shenzhen Institutes of Advanced Technology (CAS), China

Reviewed by:

Fajin Dong, Shenzhen People’s Hospital, China
Dirong Zhang, Peking University Shenzhen Hospital, China  

Copyright: © 2018 HE, WANG, HU, CHEN, LING and WEI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Ms. XIAO YAN WANG, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China, ultrasoundwang@sina.com
Ms. QIAO HU, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China, xyyxyhq@163.com