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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.00174

Chinese Medicines Improve Perimenopausal Symptoms Induced by Surgery, Chemoradiotherapy or Endocrine Treatment for Breast Cancer

 Shuo Wang1, Hongsheng Lin2 and  Weihong Cong3*
  • 1China-Japan Friendship Hospital, China
  • 2Guang’anmen Hospital, China Academy of Chinese Medical Sciences, China
  • 3Xiyuan Hospital, China

The application of surgery, chemoradiotherapy and endocrine treatment successfully increase survival rates of breast cancer patients. However, perimenopausal symptoms, the main side effects of these treatments, often afflict patients and reduce their quality of life. Perimenopausal symptoms include vasomotor symptoms, sleep problems, arthromuscular symptoms and osteoporosis. Currently, there is no satisfactory treatments for perimenopausal symptoms that result from these treatments. Therefore, alternative and complementary therapies including herbal medicines represented by Chinese medicines (CMs), acupuncture, massage and psychotherapy are increasingly being expected and explored. In this paper, we review the effects and potentials of several CM formulae, along with some active ingredients or fractions from CMs, Chinese herbal extracts and other herbal medicines, which have drawn attention for improving perimenopausal symptoms in breast cancer patients. We also elaborate their possible mechanisms. Moreover, further studies for evaluation of standardized clinical efficacy should be scientifically well-designed and continuously performed to investigate the efficacy and mechanisms of CMs for perimenopausal symptoms due to breast cancer therapy. The safety and value of estrogen-containing CMs for breast cancer should also be clarified.

Keywords: Herbal Medicine, Complementary Therapies, breast cancer, Perimenopausal symptoms, Quality of Life, Chinese medicine

Received: 29 Jul 2018; Accepted: 11 Feb 2019.

Edited by:

Hongjie Zhang, Hong Kong Baptist University, Hong Kong

Reviewed by:

Jianping Chen, Shenzhen Traditional Chinese Medicine Hospital, China
Miaomingsa M. 苗, Institute for Genetic and Biomedical Research (IRGB), Italy  

Copyright: © 2019 Wang, Lin and Cong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Weihong Cong, Xiyuan Hospital, Beijing, China,