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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.00551

The role of autophagy in acute myocardial infarction

 Du Wu1*, Kangfeng Zhang1 and Pengfei Hu2
  • 1Department of Internal Medicine, The WuYun Mountain Sanatorium of Hangzhou, China
  • 2Department of Cardiology, the Second Affiliated Hospital of Zhejiang Chinese Medical University, China

Acute myocardial infarction refers to a sudden death of cardiomyocytes, which leads to a large mortality worldwide. To attenuate acute myocardial infarction, strategies should be made to increase cardiomyocyte survival, improve postinfarcted cardiac function as well as reversing the process of cardiac remodeling. Autophagy, a pivotal cellular response, has been widely studied to be involved in various kinds of diseases. In the recent few years, the role of autophagy in diseases has been drawn increasing attention to by researchers. Here in this review, we mainly focus on the discussion of the effect of autophagy on the pathogenesis and progression of acute myocardial infarction under ischemic and ischemia/reperfusion injuries. Furthermore, several popular therapeutic agents and strategies taking advantage of autophagy will be described.

Keywords: acute myocardial infarction, Autophagy, cardiomyocyte, Ischemia, Reperfusion

Received: 29 Jan 2019; Accepted: 01 May 2019.

Edited by:

Changhua Wang, Wuhan University, China

Reviewed by:

Rodrigo Troncoso, Universidad de Chile, Chile
Zully Pedrozo, Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Universidad de Chile, Chile  

Copyright: © 2019 Wu, Zhang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Du Wu, The WuYun Mountain Sanatorium of Hangzhou, Department of Internal Medicine, Zhejiang, China, wd119033@163.com