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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01148

Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia

 Hui Min Yap1,  Daud A. Israf1*, Hanis S. Harith1,  Chau Ling Tham1 and Mohd R. Sulaiman1
  • 1Putra Malaysia University, Malaysia

Increased ASM mass, primarily due to ASM hyperplasia, has been recognized as a hallmark of airway remodelling in asthma. Increased ASM mass is the major contributor to the airway narrowing, thus worsening the bronchoconstriction in response to stimuli. Inflammatory mediators and growth factors released during inflammation induce increased ASM mass surrounding airway wall via increased ASM proliferation, diminished ASM apoptosis and increased ASM migration. Several major pathways, such as MAPKs, PI3K/AKT, JAK2/STAT3 and Rho kinase, have been reported to regulate these cellular activities in ASM and were reported to be interrelated at certain points. This article aims to provide an overview of the signalling pathways/molecules involved in ASM hyperplasia as well as the mapping of the interplay/crosstalk between these major pathways in mediating ASM hyperplasia. A more comprehensive understanding of the complexity of cellular signalling in ASM cells will enable more specific and safer drug development in the control of asthma.

Keywords: airway remodelling, ASM hyperplasia, ASM proliferation, ASM migration, ASM apoptosis

Received: 25 Jun 2019; Accepted: 06 Sep 2019.

Copyright: © 2019 Yap, Israf, Harith, Tham and Sulaiman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Daud A. Israf, Putra Malaysia University, Seri Kembangan, 43400, Selangor Darul Ehsan, Malaysia, daudaia@upm.edu.my