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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01153

Nanoparticles in the Treatment of Infections Caused by Multidrug-resistant Organisms

  • 1Department of Internal Medicine, College of Medicine, National Cheng Kung University, Taiwan
  • 2Department of Internal Medicine, National Taiwan University Hospital, Taiwan

Nanotechnology, the use of materials with dimensions on the atomic or molecular scale, has become increasingly utilized for medical applications and is of great interest as an approach to kill or reduce the activity of numerous microorganisms. Infections caused by multidrug-resistant organisms (MDROs) are emerging causes of morbidity and mortality worldwide. The optimal treatment route for infections caused by MDROs is often unclear, and the antibiotic options are limited. These challenges highlight the critical demand for alternative and effective antimicrobial strategies. The physical structure of a nanoparticle itself and the way in which it interacts with and penetrates into bacteria appear to provide unique bactericidal mechanisms. Coupling nanoparticles and natural-based antimicrobials (or other repurposed compounds) to inhibit bacterial efflux pumps, biofilm formation, quorum sensing, and possibly plasmid curing, are some of the strategies to combat MDROs. Combinatorial therapy with metallic nanoparticles, as an adjunct to existing antibiotics, may aid in restraining the mounting menace of bacterial resistance. In this review, we will summarize the current researches on nanoparticles and other nanomaterials and how they are applied or can be applied in the future to fight MDROs.

Keywords: nanoparticle, antimicrobial resistance, pharmacokinetics, Pharmacodynamics, Toxicity

Received: 01 Feb 2019; Accepted: 09 Sep 2019.

Copyright: © 2019 Lee, Hsueh and Ko. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Wen-Chien Ko, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, winston3415@gmail.com