%A Fang,Yuanying %A Hu,Daoyong %A Li,Huilan %A Hu,Jianguo %A Liu,Yanhua %A Li,Zhifeng %A Xu,Guoliang %A Chen,Lanying %A Jin,Yi %A Yang,Shilin %A Yang,Zunhua %D 2019 %J Frontiers in Pharmacology %C %F %G English %K Pulsatilla saponin D,Synthesis,Antiproliferative activity,acute toxicity,Apoptosis %Q %R 10.3389/fphar.2019.01208 %W %L %M %P %7 %8 2019-October-15 %9 Original Research %+ Guoliang Xu,Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine,China,xuguoliang6606@126.com %+ Zunhua Yang,College of Pharmacy, Jiangxi University of Traditional Chinese Medicine,China,xuguoliang6606@126.com %# %! Pulsatilla Saponin D derivatives as promising anticancer agents %* %< %T Synthesis, Biological Evaluation, and Mode of Action of Pulsatilla Saponin D Derivatives as Promising Anticancer Agents %U https://www.frontiersin.org/articles/10.3389/fphar.2019.01208 %V 10 %0 JOURNAL ARTICLE %@ 1663-9812 %X A series of ester and amide derivatives of triterpenoid saponin Pulsatilla saponin D (PSD) were designed, synthesized, and evaluated for their antiproliferative activity. Compounds 1 and 6 displayed 1.7–8.3 times more potent cytotoxicity (IC50 = 1.2–4.7 and 1.7–4.5 μM, respectively) against five human tumor cell lines (SMMC-7721, MCF-7, NCI-H460, A549, and HCT-116) in vitro and lower acute toxicity to mice in vivo than did PSD. Furthermore, compound 6 was observed to show potent tumor growth inhibition against mice H22 hepatocellular cells (49.8% at 20 mg/kg) and induce cell cycle at G1 phase and apoptosis in HCT-116 cells.