Actinidia chinensis Planch.: A Review of Chemistry and Pharmacology

Actinidia chinensis Planch. (A. chinensis), commonly known as Chinese kiwifruit, is a China native fruit, which becomes increasingly popular due to attractive economic, nutritional, and health benefits properties. The whole plant including fruits, leaves, vines, and roots of A. chinensis are used mainly as food or additive in food products and as folk medicine in China. It is a good source of triterpenoids, polyphenols, vitamin C, carbohydrate, amino acid, and minerals. These constituents render the A. chinensis with a wide range of pharmacological properties including antitumor, antioxidant, anti-inflammatory, immunoregulatory, hypolipemic, antidiabetic, and cardiovascular protective activities, suggesting that it may possibly be value in the prevention and treatment of pathologies associated to cancer, oxidative stress, and aging. This minireview provides a brief knowledge about the recent advances in chemistry, biological activities, utilization, and storage of Chinese kiwifruit. Future research directions on how to better use of this crop are suggested.

INTRODUCTION Actinidia chinensis Planch. (A. chinensis), commonly known as "Chinese kiwifruit" (English), "中华猕猴桃" (Chinese), and characterized by excessive vegetative vigor, is a woody perennial, deciduous, and functionally dioecious medicinal plant in the family Actinidiaceae (Flora of China, 2007;The Plant List, 2013). It is native to China and has been cultivated in New Zealand, United States, Greece, Italy, Chile, France, Japan, and Korea Ma et al., 2017). In China, they are mainly distributed in temperate to warm-temperate zones such as Shaanxi, Gansu, Henan, Guangdong, Guangxi, Fujian, Guizhou, Yunnan, Sichuan, as well as the middle and lower reaches of the Yangtze River basin, especially in Yiling district in Yichang city, Hubei province (Figure 1) (Flora of China, 2007). There are 13 A. chinensis cultivars, especially "Hongyang, " "Jintao, " and "Huayou, " are developed for commercial production in China (Sharon, 2016), and more than three ones such as "Sungold, " "Charm, " and "Hort16A" developed in New Zealand (Henare, 2016) (Table 1).
There are two varieties accepted by The Plant List that include A. chinensis and A. chinensis var. setosa H.L. Li (The Plant List, 2013). The fruit of A. chinensis is the largest one in Actinidia genus, and it has the greatest economic, medicinal, and edible significance in terms of production and utilization. Its relevant pictures are showed in Figure 2. Generally, Chinese kiwifruit with a crosssectional radius of about 3 cm is oval-shaped densely covered with yellowish-brown hairs. The flesh color of fruit skin is green to yellow, and the average fruit weight is 20-120 g. The fruit is a tasty, nutritious food that can be eaten fresh directly. Today, a range of kiwifruit processed products with October 2019 | Volume 10 | Article 1236 Frontiers in Pharmacology | www.frontiersin.org TABLE 1 | A. chinensis cultivars developed for commercial production (Henare, 2016 significant share of the daily value ( Table 2). Pharmacological results have revealed various promising bioactivities to A. chinensis including antitumor, antioxidant, anti-inflammatory, antimicrobial, immunoregulatory, hypolipemic and antidiabetic, cardiovascular protective, hypnotic effects, and ACE inhibitory activities (Deng et al., 2013;Niu et al., 2016;Sun et al., 2017;Xia et al., 2017;Deng et al., 2018;Hou et al., 2018;Fang et al., 2019). Much of these bioactivities of A. chinensis are consistent with those observed in traditional folk medicine. More importantly, A. chinensis showed significantly antitumor and antioxidant properties, and these effects could be depended on the presence of a range of triterpenoids, polysaccharide, and phenolic compounds (Chang and Case, 2005;Wei et al., 2018;Fang et al., 2019). However, the information on the chemical and biological activities of A. chinensis is scattered. In this review, we intend to systematically summarize the recent advances in nutritional composition, chemistry, and biological activities of A. chinensis and also provide future research directions for better utilize and develop it as a sustainable crop.
Thus, these data suggest that kiwifruit is an interesting fruit for daily nutrition and energy suppliers.

Phytochemicals
A range of phytochemicals, including triterpenoids, saponins, and phenolic compounds (flavonoids, polyphenols, anthraquinones, and coumarins) varying in structures, were found and identified in A. chinensis. The major constituents isolated and identified in leaves and roots of A. chinensis are listed in Table 4.

Triterpenoids
Currently, triterpenoids have been the major research focus of A. chinensis components due to their promising antitumor properties. To date, 42 triterpenoids have been isolated and identified mainly from roots of A. chinensis. The commonly triterpenoids found in roots of A. chinensis are 12-en-28-oic acids of oleanane and ursane type. It is noteworthy that some of these triterpenoids (1-2, 7, 15-18, 21, 25-26, 29-30, and 34-40) have significant antitumor activity and deserve further research and development.

Phenolic Compounds
The phenolic compounds abundantly presented in different botanical parts of A. chinensis, and they have drawn increasing attention. These compounds include phenols, flavonoids, and flavanols are characterized by antitumor, antioxidant, and free radicals scavenging properties. HPLC-PAD and UPLC-QqQ-MS/ MS-based methods have been used generally for the identification and quantification of these phenolic compounds (Ma et al., 2017;Jiao et al., 2019). The total phenolic, flavonoid, and flavanol contents from young A. chinensis kiwifruits "Zespri ® SunGold Kiwifruit" growing in 20 days are 82.84 mg GAE/g FDW, 30.08 catechin/g equivalents FDW, and 20.20 catechin/g equivalents FDW. Meanwhile, the total phenolic, flavonoid, and flavanol contents presented in young A. chinensis kiwifruits growing in 60 days and mature kiwifruits are gradually decreasing, indicating polyphenol content possesses a decreasing pattern during fruit ripening (Jiao et al., 2019). The major chemical composition of phenolics detected in young "Zespri ® SunGold Kiwifruit" are epicatechin, quercitrin, rutin, catechin, chlorogenic acid, ferulic acid, and vanillic acid. Based on UPLC-TOF/MS and UPLC-QqQ/ MS method, Zhao et al., 2014 showed that the radix A. chinensis contained catechin derivatives, quinic acid derivatives, coumarin derivatives, caffeic acid, and p-coumaric acid , showing that A. chinensis appears to be a good source of phenolics.

Quality Determination
Ripe kiwifruit is susceptible to environmental and itself. Usually, human sensory evaluation method can directly identify the fruit shape, color, surface, pulp, and flavor, but there is little information about swelling, ripening, and other agents present in fruit. Physical and chemical method including firmness and microbial are used effectively to determine the quality condition of kiwifruit. Some new instrument detection methods with accurate analysis ability such as GC, GC-MS, HPLC, UPLC-QqQ-MS/MS, and electronic nose combined with surface acoustic wave resonator are developed for the fruit and its products quality rapid analysis (Kvesitadze et al., 2001;Montefiori et al., 2005;Liu and Hui, 2015;Jiao et al., 2019). As to radix A. chinensis, the systematical method like UPLC-TOF/MS and UPLC-QqQ/MS is commonly applied to quality evaluation and active components analysis for A. chinensis . Therefore, there are many high accurate analysis methods for rapid quality evaluation, but there is a lack of effective and standardized quality and safety standard for kiwifruit in China. Thus, there is an urgent demand for developing specific functional components and quality evaluation indicators for standardization and quality control of the fruit and its products.

Biological Activities
A. chinensis contains a range of bioactive compounds accounting for natural pharmacological properties including antitumor, antioxidant, anti-inflammatory, immunoregulatory, hypolipemic, antidiabetic, and cardiovascular protective activities, and most of these biological activities support its traditional use. Table  5 shows the major biological activities of compound or extract from A. chinensis.

Antitumor Activity
Crude extracts, fractions, and isolated compounds from A. chinensis exhibited strong inhibition against tumor growth in various forms of human cancer cells. These cancer cells were hepatocellular carcinoma cells HepG2 (Xu et al., 2010;Zuo et al., 2012) A large number of triterpenoids in roots of A. chinensis especially those with carboxyl group showed marked cytotoxicity against various types of cancer cells in vitro. Especially, compounds 1-2, 7, 15-18, 21, 25-26, 29-30, 34-40, and 43-46 exhibited remarkable antitumor activity against on A549, HepG2, LVOV, MCF-7, HeLa, and/or HepG2 in vitro (Table 5). Additionally, the polysaccharide of Hogyang fruit showed notable inhibitory against tumor cells lines SGC7901, MCF-7, HT29, HepG2, and NCI-H460 with IC 50 of were 0.28, 0.31, 0.58, 0.64, and 0.65 µM, respectively (Xia et al., 2017). In vivo, a polysaccharide isolated from the roots of A. chinensis showed antitumor activity by prolonging the life of EAC or P388 cellsinduced tumor mice and inhibiting the DNA synthesis in EAC cells (Lin, 1988). Early treatment and long-term treatment with water extracts of roots from A. chinensis with 2 g/kg/day strongly attenuated the malignant behavior of HCC in mice by decreasing DLX2 expression (Fang et al., 2019).
The molecular mechanism of the inhibition against tumor growth and the apoptosis promoting of the fractions and isolated compounds were due to downregulate DLX2 gene expression and VEGFR2/Src/FAK pathway, inhibit cholesterol metabolism by upregulating PCSK9 signaling pathway, regulate gene encoding laminin subunit beta-3 pathways, and decreased NF-κB and EP3 expression. Meanwhile, the antioxidation and anti-inflammation are also important and possible mechanisms. The triterpenoids, polysaccharides, and phenolic compounds were identified as October 2019 | Volume 10 | Article 1236 Frontiers in Pharmacology | www.frontiersin.org   the major bioactive compounds in the extract from A. chinensis roots with antitumor properties (Chang and Case, 2005;, which provides new way to search for treating cancers with natural therapeutic compounds. Overall, A. chinensis has prominent antitumor potential and has a good health benefit for people, however, the further in vivo and clinical studies on antitumor properties of A. chinensis are needed for confirmation.

Antioxidant Activity
Antioxidant activity of bioactive compounds of A. chinensis have been the mostly studied by various in vitro and in vivo assays. These in vitro assays consisted of both chemical and biological assays like DPPH, ABTS, FRAP, HO·, ORAC, oxidative stress by H 2 O 2 , and lipid oxidation (Chai et al., 2014;Lee et al., 2015;Hwang et al., 2017;Deng et al., 2018). The in vivo assays were based on SOD, GSH, ALT, AST, oxidative DNA damage, and lipid oxidation (Iwasawa et al., 2011;Sun et al., 2017;Deng et al., 2018;. The above results showed that A. chinensis is a good source of bioactive compounds with antioxidant properties to various extents. The antioxidant capacities of kiwifruit are greatly attributed to polyphenols, flavonoid, unsaturated fatty acid, and vitamin C. In addition, the different extraction methods, different plant parts, and genetic diversity of kiwifruit demonstrated different antioxidant activities. The peel showed the strongest antioxidant activity, followed by the pulp and the core. The antioxidant activity of kiwifruit peel was mainly depended on plenty of phenolic substances, and the antioxidant activity of the pulp was mainly attributed to the existence of a large amount of vitamin C . The seed oil of Hort 16A and Hongyang are attractive materials rich in unsaturated fatty acid demonstrated radical scavenging capacities for FRAP, DPPH, HO·, and ORAC with IC 50 of 3.3 mgTrolox/kg, 32.4 mg/ml, 1.04 mg/ml, 1.69 mgTrolox/kg, and 107.3 mgTrolox/kg, 31.4 mg/ml, 1.09 mg/ml, 1.99 mgTrolox/kg, respectively (Deng et al., 2018). The radical scavenging capacities of fresh and freeze-dried Hort 16A rich in phenolics and flavonoids for ABTS, DPPH, and ORAC were 8.8, 8.8, 98.3, and 6.0, 5.0, and 40.3 mg VCE/g, respectively (Hwang et al., 2017). The radical scavenging capacities of Red sun and Cuiyu rich in phenolics and flavonoids for ABTS, DPPH, ORAC, and FRAP were 1.35, 1.01, 10.78, 1.50 and 1.32, 0.9, 8.87, 1.28 mg VCE/g, respectively . Oral administration of kiwifruit protected lymphocytes against oxidative DNA damage, inhibit lipid oxidation in mice, increased SOD and GSH, and lowered ALT and AST levels in the patients . Therefore, A. chinensis possess confirmed antioxidant capacity and it seems that appropriate extraction methods, appropriate genotypes, and plant parts can be screened to maximize the antioxidant properties of A. chinensis.

Anti-Inflammatory Activity
Anti-inflammatory activity of A. chinensis has been proved in vivo and in vitro models. On high-fat diet-induced obese C57BL/6 mice models, consecutive consumption the seeds oil of A. chinensis with 1.0 and 3.0 ml/kg·bw ameliorated obesity-induced inflammation by down-regulating the mRNA expression of related to inflammation adipokines, such as TNF-α, IL-6, IL-1β, COX-2, and iNOS . The aqueous and ethyl acetate extracts demonstrated anti-inflammatory activity in inflammatory bowel disease models of the IL-10 gene-deficient mice (Edmunds et al., 2012). In patients with type-2 diabetes mellitus, the fruit juice of A. chinensis showed preventative activity on inflammation by activating Keap1 and Nrf2 via upregulating miR-424 . On the cellular level, polyphenols mainly composed of protocatechuic acid, p-hydroxybenzoic acid, p-coumaric acid, caffeic acid, and ferulic acid from seeds of A. chinensis at concentration of 40 and 60 μg/ml for 12 h decreased the secretion of pro-inflammatory cytokines IL-1β and TNF-α in LPS-induced RAW 264.7 cells (Deng et al., 2016). Therefore, the anti-inflammatory potential A. chinensis seeds mainly depend on the synergetic effect of these polyphenols, and it may be used to prevent a variety of inflammation related diseases.

Antibacterial Activity
All the extracts including skin, pulp, seeds, and stems showed bactericidal against Staphylococcus aureus, Streptococcus pyogenes, S. faecalis, Salmonella typhi, Proteus mirabilis, Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumonia. The skin and pulp extracts showed inhibition activity against S. aureus and S. pyogenes with MIC values of 8 and 4 μg/ ml, but they showed moderate inhibition activity against S. faecalis, S. typhi, P. mirabilis, P. aeruginosa, E. coli, and K. pneumonia with MIC values ranging from 16 to 128 μg/ml. The leaves and stems extract just inhibited S. pyogenes and P. aeruginosa with MIC values of both 64 and 32 μg/ml. The seeds extracts showed an exclusively bacteriostatic activity against these selected strains of bacteria with MIC values of between 1 and 8 μg/ml (Basile et al., 1997). Polyphenol from seeds of A. chinensis showed significant bactericidal against Bacillus cereus, B. subtilis, Shigella flexneri, and Salmonella Typhi, and bacteriostatic against B. thuringiensis. We can find that the antimicrobial activity of the polyphenol extract on gram-positive bacteria is higher than that of gramnegative bacteria (Deng et al., 2013). Therefore, kiwifruit seeds are potential food processing material for their antimicrobial activity.

Immunoregulatory Activity
Consumption of the aqueous extracts of whole fresh fruit of Hort16Aat 375 mg/kg for 12 days enhanced both innate and acquired immunity in cholera vaccine and tetanus/diphtheria vaccine models in Balb/c mice, showing a beneficial effect on healthy (Shu et al., 2008). The homopolysaccharide derivatived by O-sulfation from the roots of A. chinensis at concentration of 10 and 50 μg/ml activated phagocytic activity and increased NO production of RAW 264.7 macrophages, and the activity of sulfated polysaccharides is strongly related to the degree of the sulfation (Niu et al., 2016), and treatment with 50-300 μg/ml water-soluble polysaccharides dose-dependently stimulated NO production and phagocytic activity of RAW 264.7macrophages (Zhang et al., 2015). It remains to clarify the detailed mechanism of immunoregulatory activity and the responsible compositions for this valid action.

Hypolipemic and Antidiabetic Activities
Administered the seed oil of A. chinensis rich in fatty acids at 1.0 and 3.0 ml/kg·bw daily over 12 consecutive weeks significantly lowered bodyweight gain, inguinal fat tissue weight, and the accumulation of TC, TG, HDL-C, and LDL-C in liver of the high-fat diet-induced obese C57BL/6 mice. Meanwhile, long-term consumption of the seed oil of A. chinensis up-regulated the expression of thermogenesis-related genes like PPAR-γ, UCP1, PGC1-α, and PRDM16, down-regulated FAS expression, and altered the gut microbiota by decreasing the Firmicutes-to-Bacteroidetes ratio . In addition, the seed oil from A. chinensis supplementation improved insulin resistance and alleviated hyperglycemia by reducing HOMA-IR index and blood glucose in high fat diet-induced obese mice . Thus, the lipid lowering potential of A. chinensis seed provide a basis theory for food industries.

Cardiovascular Protective Effects
In H9c2 rat cardiac myocytes cells induced by hypoxia in cardiomyocytes treated with angiotensin II, treatment with 1.25 and 2.5 mg/ml polysaccharide of A. chinensis alleviated cardiac hypertrophy, decreased mitochondrial dysfunction and reduced cardiomyocytes apoptosis by decreasing the apoptosisassociated genes expression like mitochondria associated-1 and caspases3/8/9, and cleaving caspases-3/8/9. Additionally, the protective effects of polysaccharide against hypoxia-induced apoptosis may be attributable to inactivate the ERK1/2 and PI3K/ AKT signaling pathways . The polysaccharide of A. chinensis can be potentially used in the treatment of heart disease. However, it is noteworthy that polysaccharide at high dose (10 mg/ml) suppressed the cardiomyocytes viability.

Hypnotic Effects
Oral administration of ethanol extracts from A. chinensis peel at dose of 250, 500, and 1,000 mg/kg dose-dependently decreased sleep latency and increased sleep duration in pentobarbitaltreated mice. Especially, the sequentially partitioned with ethyl acetate fraction rich in flavonoids (1.63 mg QE/g) at 250 mg/kg exert significantly hypnotic effects and this sedative-hypnotic activity could be inhibited by GABA A -BZD receptor antagonist flumazenil. The flavonoids may be attributable to hypnotic activity via allosteric GABA A -BZD receptor modulation, but the precise mechanisms and the existing individual flavonoids are needed to be evaluated in the future .

Dermatological Activity
The raw polysaccharides with >90% carbohydrate and 5.2% residual protein from the fresh fruit of A. chinensis at 10 μg/ml showed a significantly proliferation-promoting on cell proliferation rates of HaCaT cell line and primary keratinocytes (NHK), and it also significantly promoted proliferation of human dermal fibroblasts at 132 and 198 μg/ml. Meanwhile, treatment of the polysaccharides at 200 μg/ml significantly stimulated ATP-synthesis, promoted mitochondrial activity and energy metabolism of HaCaT keratinocytes, and significantly increased collagen synthesis in dermal skin equivalents (Deters et al., 2005). Kiwifruit pericarp proanthocyanidins mainly contained B-type propelargonidins, procyanidins, procyanidins gallate, and prodelphinidins showed strongly inhibition activity on tyrosinase, indicating that it can be used as whitening agents (Chai et al., 2014).

Cytochrome P450 Enzyme Inhibitory Activities
Cytochrome P450 system in liver plays an important role in drug metabolism. It transforms drug from hydrophobic to hydrophilic, which is easier to excrete. The 90% EtOH extract of A. chinensis root at 50 μg/ml exhibited inhibition activities on CYP2C9, CYP2D6, and CYP3A4 in human liver tissue with the 69.0, 76.3, and 53.3% of remaining activity, respectively. The inhibitory effect of the crude extract could be largely attributed to the presence of triterpenoids (Xu et al., 2016). It is worth noting that the combination of crude extracts or these triterpenoids with other medical herbs or drugs may lead to drug interaction with cytochrome CYPs at pharmacokinetic and pharmacodynamic levels, which indicates that people should cautiously consume A. chinensis fruit when taken medicine.

Processing and Utilization
Chinese kiwifruit is a very high nutritional value of nourishing and consumers' favorite fruit, which has shown application potential in food, medicine, and health products industry. China is the largest kiwifruit producer in the world. In 2016, kiwifruit production in China reached 2.41 million tons per year, accounting for 56.0% of the world's total kiwifruit production (United Nations Food and Agriculture Organization, 2016). To date, a series of commercially available products has been processed due to abundant nutrient substance and claimed health benefits. These Chinese kiwifruit related products include sliced fruit, juice, preserved fruit, yogurt, wine, canned fruit, dried kiwi slices, fruit vegetable juice drinks, biscuits, milk beverage, whipped cream, baked goods, vinegar, and oil capsule. Furthermore, various different parts of A. chinensis showed different uses. Briefly, the leaves contain protein, starch, and polyphenols, which may be developed as an excellent source of natural products. The beautiful and fragrant of Chinese kiwifruit flowers rich in honey juice and volatiles can be used as high-quality honey source. Kiwifruit peel residue as sources of high-quality pectin can be used as functional ingredient for food products. Chinese kiwifruit seeds rich in essential fatty acids, protein, and dietary fiber can be used in food and health products industry (Xie, 1975;Garcia et al., 2012). The roots and barks contain ursolic acid, oleanolic acid, and quercetin, which have antitumor effect against liver cancer, lung cancer, gastric cancer, esophageal cancer, colorectal cancer, and cervical cancer (Chang and Case, 2005;Xu et al., 2010;Wei et al., 2018). The different parts of A. chinensis are widely used as pharmaceutical raw materials in medicine for prevention and treatment of tumors. In addition, the various claimed nutritional and pharmacological properties including strong antitumor, antioxidation, and antiinflammatory potential of various extracts or active compounds of A. chinensis indicated that they could be further developed for functional food with added-commercial value or effective and safe drug formulations.

Storage Methods
Chinese kiwifruit has a short postharvest life because of fast softening and serious decay. Preservation of Chinese kiwifruit for prolonged periods is particularly important. Freezing and frozen storage is currently the most common method, which can effectively inhibit the softening of kiwifruit and prolong its postharvest life. However, kiwifruit is cold-sensitive and very susceptible to chilling injury when storage at the temperature between −2°C and 2.5°C for a long time (Gerasopoulos et al., 2006;Ma et al., 2014). Interestingly, dipped by water for 10 min at 45°C to low temperature storage can prevent chilling injury development to kiwifruit. Meanwhile, the kiwifruit pretreated at 45°C and then stored at 0°C for 90 days showed higher firmness and soluble solids content, and MDA content and lipoxygenase activity in kiwifruit are reduced. However, pretreated at 20 and 55°C were ineffective at alleviating chilling tolerance . Various other treatments including preharvest calcium chloride sprays (Gerasopoulos and Drogoudi, 2005), putrescine , preharvest chilling (Sfakiotakis et al., 2005), and gradual cooling  have also been used to alleviate chilling injury in kiwifruit. After harvest, kiwifruit is highly perishable, and its nutritional ingredients and quality decline rapidly due to the influence of internal biochemical reactions and external environment. The modified atmosphere packaging, chitosan, 1-methylcyclopropene, ClO 2 , ozone, tea polyphenols, protein, lipid composite film, oxalate, salicylic acid, and citric acid have been used individually or combined to alleviate physicochemical quality changes for postharvest of kiwifruit (Huang et al., 2017). The ozone treatment induced the ripening process, delayed the microbial growth, and influenced the content of vitamin C, polyphenols, flavonoids, and carotenoids (Goffi et al., 2019). The chitosan combined with salicylic acid treatment during storage at room temperature for 14 days provides a significantly effective preservative effect by delayed vitamin C and soluble solids decomposition, inhibiting moisture loss and acidity change, and maintaining texture and surface color of Chinese kiwifruit in 14 days of storage at room temperature (Huang et al., 2017).

CONCLUSIONS
Chinese kiwifruit and related products are increasingly popular throughout the world due to the remarkably economic, nutritional, and health benefits values. It is a good source of phenolic compounds, vitamin C, carbohydrates, sugars, amino acids, and minerals. Of particular note in kiwifruit is vitamin C and minerals K. The phenolic compounds present in Chinese kiwifruit are organic acids and flavonoids, and fruit peel and flesh, leaf, vine, and roots also contain a variety of these phenolic components. The major components of the roots are triterpenoids characterized by 12-en-28-oic acids of oleanane and ursane type. Terpenes, straight chain alkenes, alcohols, and esters were dominant volatile components in flowers and roots of A. chinensis. These chemical compounds render the A. chinensis with a range of sensory quality, nutritional, and pharmacological properties as proved by in vitro and in vivo studies. The claimed biological activity of isolated compounds, fractions, or crude extracts include antitumor, antioxidant, anti-inflammatory, antibacterial, immunoregulatory, hypolipemic, antidiabetic, and cardiovascular protective effects. Of particular note is that these claimed biological activities such as antitumor, antioxidant, and immunoregulatory may be greatly attributed to the existence of triterpenoids, polyphenols, flavonoid, polysaccharide, unsaturated fatty acid, and vitamin C. These findings suggest that Chinese kiwifruit can be useful in the prevention and treatment of pathologies associated to cancer, oxidative stress, and aging.
There are also research opportunities to better development, utilization, and protection kiwifruit for human consumption. Cytochrome P450 inhibitory activities, toxicity analysis, qualitative and quantitative metabolite research, effective and standardized quality standard building, and clinical studies should be encouraged to conducted for safe daily consumption. Meanwhile, the synergism and attenuation effects, metabolic behavior of various ingredients, as well as the in vivo and molecular mechanisms studies responsible for the observed biological properties should be conducted. It is also found that some of the A. chinensis cultivars were only supported by a few studies, and confirmative studies should be conducted to verify their health effects. Apart from the fruit, other plant parts of kiwifruit including leaves and roots should also be explored for effective utilization. The effective method and technology for the storage and preservation of kiwifruit during preharvest and postharvest remain to be explored to avoid the frequent chilling damage, soft rot, and mildew, and also decrease and improve the change of the chemical profile and bioactivity properties during storage.

AUTHOR CONTRIBUTIONS
XC and YM obtained the literatures. JF, ZZ, and XH wrote the manuscript. XH, LH, and YL gave ideas and edited the manuscript. All authors approved the paper for publication.