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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01283

8-formylophiopogonanone B antagonizes paraquat-induced hepatotoxicity by suppressing oxidative stress

Jing-Yu Qian1, Ping Deng2,  Zheng-ping Yu1*,  Yi D. Liang1, Li Pang1, Li-Chuan Wu1, Ling-Ling Yang2 and Zhou Zhou3
  • 1Guangxi University, China
  • 2Army Medical University, China
  • 3Zhejiang University, China

Flavonoids are some of the most important natural products with a variety of physiological activities. 8-formylophiopogonanone B (8-FOB) is a naturally existing homoisoflavonoid in Ophiopogon japonicus. Paraquat (PQ) has been widely used as a potent herbicide and has high toxicity in humans. The goal of the present study was to investigate whether 8-FOB could protect against PQ-induced hepatotoxicity in vitro and in vivo. We first tested the protective effects of 8-FOB on PQ-induced cytotoxicity in L02 cells by determining cell viability, intracellular oxidative stress levels, mitochondrial function and apoptosis in vitro. To verify the protective effects of 8-FOB, we pretreated mice with 8-FOB and assessed liver function, hepatic oxidative stress and histopathological changes after PQ administration. Our results revealed that 8-FOB could antagonize PQ-induced hepatotoxicity in vitro and in vivo. The antagonistic effects could be attributed to suppressing oxidative stress, preserving mitochondrial function, and inhibiting apoptosis. The present study is the first to document that 8-FOB, a homoisoflavonoid compound, is an effective antioxidant for antagonizing PQ-induced hepatotoxicity.

Keywords: 8-formylophiopogonanone B, Paraquat (PQ), Hepatotoxicity, Oxidative Stress, Apoptosis

Received: 13 Aug 2019; Accepted: 07 Oct 2019.

Copyright: © 2019 Qian, Deng, Yu, Liang, Pang, Wu, Yang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Zheng-ping Yu, Guangxi University, Nanning, Guangxi Zhuang Region, China,