TY - JOUR
AU - Kistamás, Kornél
AU - Veress, Roland
AU - Horváth, Balázs
AU - Bányász, Tamás
AU - Nánási, Péter P.
AU - Eisner, David A.
PY - 2020
M3 - Review
TI - Calcium Handling Defects and Cardiac Arrhythmia Syndromes
JO - Frontiers in Pharmacology
UR - https://www.frontiersin.org/articles/10.3389/fphar.2020.00072
VL - 11
SN - 1663-9812
N2 - Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization of the ion currents at the cellular level to drive action potentials and to maintain action potential propagation and electrical homogeneity at the tissue level. Any imbalance in Ca2+ homeostasis of a cardiac myocyte can lead to electrical disturbances. This review aims to discuss cardiac physiology and pathophysiology from the elementary membrane processes that can cause the electrical instability of the ventricular myocytes through intracellular Ca2+ handling maladies to inherited and acquired arrhythmias. Finally, the paper will discuss the current therapeutic approaches targeting cardiac arrhythmias.
ER -