TY - JOUR AU - Zhang, Yazhi AU - Qiu, Yining AU - Wang, Zhujun AU - Wang, Ran AU - Jin, Runming AU - Hinkle, Louis Edward AU - Wu, Xiaoyan PY - 2020 M3 - Case Report TI - High-Dose Methotrexate-Induced Idiopathic Intracranial Hypertension in Infant Acute Lymphoblastic Leukemia JO - Frontiers in Pharmacology UR - https://www.frontiersin.org/articles/10.3389/fphar.2020.00839 VL - 11 SN - 1663-9812 N2 - A 7-month-old baby girl with acute lymphoblastic leukemia (ALL) presented with bulging anterior fontanelle after completing the first and second courses of high-dose methotrexate (HD-MTX) chemotherapy. Between courses, the infant recovered and was discharged. Prior to the third and fourth HD-MTX courses, the baby girl was administered infusions of dexamethasone, which prevented recurrence of neurological side effects observed after the first and second courses of HD-MTX. To our knowledge, this is the first reported case of HD-MTX-induced idiopathic intracranial hypertension in infants, and that prophylactic use of dexamethasone can be applied to prevent acute intracranial hypertension following HD-MTX infusion. ER -