AUTHOR=Akone Sergi Herve , Ntie-Kang Fidele , Stuhldreier Fabian , Ewonkem Monique Bassomo , Noah Alexandre Mboene , Mouelle Simon Eitel Misse , Müller Rolf 

TITLE=Natural Products Impacting DNA Methyltransferases and Histone Deacetylases

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00992

DOI=10.3389/fphar.2020.00992

ISSN=1663-9812

ABSTRACT=Epigenetics refers to heritable changes in gene expression and chromatin structure without change in a DNA sequence. Several epigenetic modifications and regulators have been reported including DNA methylation, histone post-translational modifications, chromatin remodeling, and non-coding RNAs. Emerging evidence has revealed that epigenetic dysregulations are involved in a wide range of diseases including cancers. Therefore, the reversible nature of epigenetic modifications concerning activation or inhibition of enzymes involved could be promising targets and useful tools for the elucidation of cellular and biological phenomena. In this review, emphasis is laid on natural products that inhibit DNA methyltransferases and histone deacetylases making them promising candidates for the development of lead structures for anticancer-drugs targeting epigenetic modifications. We also discussed potential roadblocks associated with their use as anticancer leads.