AUTHOR=Caruso Vanni , Zuccarini Mariachiara , Di Iorio Patrizia , Muhammad Ishaq , Ronci Maurizio TITLE=Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake JOURNAL=Frontiers in Pharmacology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.655989 DOI=10.3389/fphar.2021.655989 ISSN=1663-9812 ABSTRACT=

The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake. In this review, we provide an integrative view of the molecular mechanisms leading to changes in feeding behaviour within hypothalamic neurons following purinergic receptor activation. We also highlight the importance of purinergic signalling in metabolic homeostasis and the possibility of targeting its receptors for therapeutic purposes.