TY - JOUR AU - Zhang, Lin AU - Zhu, Jiahua AU - Wang, Xuyuan AU - Yang, Juan AU - Liu, Xiao Fan AU - Xu, Xiao-Ke PY - 2021 M3 - Original Research TI - Characterizing COVID-19 Transmission: Incubation Period, Reproduction Rate, and Multiple-Generation Spreading JO - Frontiers in Physics UR - https://www.frontiersin.org/articles/10.3389/fphy.2020.589963 VL - 8 SN - 2296-424X N2 - Understanding the transmission process is crucial for the prevention and mitigation of COVID-19 spread. This paper contributes to the COVID-19 knowledge by analyzing the incubation period, the transmission rate from close contact to infection, and the properties of multiple-generation transmission. The data regarding these parameters are extracted from a detailed line-list database of 9,120 cases reported in mainland China from January 15 to February 29, 2020. The incubation period of COVID-19 has a mean, median, and mode of 7.83, 7, and 5 days, and, in 12.5% of cases, more than 14 days. The number of close contacts for these cases during the incubation period and a few days before hospitalization follows a log-normal distribution, which may lead to super-spreading events. The disease transmission rate from close contact roughly decreases in line with the number of close contacts with median 0.13. The average secondary cases are 2.10, 1.35, and 2.2 for the first, second, and third generations conditioned on at least one offspring. However, the ratio of no further spread in the 2nd, 3rd, and 4th generations are 26.2, 93.9, and 90.7%, respectively. Moreover, the conditioned reproduction number in the second generation is geometrically distributed. Our findings suggest that, in order to effectively control the pandemic, prevention measures, such as social distancing, wearing masks, and isolating from close contacts, would be the most important and least costly measures. ER -