AUTHOR=Ripamonti Ugo , Klar Roland M.

TITLE=Regenerative Frontiers in Craniofacial Reconstruction: Grand Challenges and Opportunities for the Mammalian Transforming Growth Factor-β Proteins

JOURNAL=Frontiers in Physiology

VOLUME=1

YEAR=2010

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2010.00143

DOI=10.3389/fphys.2010.00143

ISSN=1664-042X

ABSTRACT=<p>Science's fascination with bone and its repair processes span for thousands of years since the ancient Greek Hippocrates, the father of Medicine, made the key discovery that bone heals without scarring. Through the centuries, several lucid investigators perceived that the extracellular matrix of bone must be a reservoir of differentiating and morphogenetic factors ultimately responsible for its pronounced healing potential (reviewed in Urist, <xref ref-type="bibr" rid="B51">1968</xref>, <xref ref-type="bibr" rid="B52">1994</xref>; Reddi, <xref ref-type="bibr" rid="B23">2000</xref>; Ripamonti et al., <xref ref-type="bibr" rid="B30">2006</xref>).</p>