@ARTICLE{10.3389/fphys.2012.00070, AUTHOR={Chastel, Claude}, TITLE={Eventual Role of Asymptomatic Cases of Dengue for the Introduction and Spread of Dengue Viruses in Non-Endemic Regions}, JOURNAL={Frontiers in Physiology}, VOLUME={3}, YEAR={2012}, URL={https://www.frontiersin.org/articles/10.3389/fphys.2012.00070}, DOI={10.3389/fphys.2012.00070}, ISSN={1664-042X}, ABSTRACT={In dengue virus infections the asymptomatic cases are much more frequent than the symptomatic ones, but their true role in the introduction and subsequent spread of dengue viruses in non-endemic regions remains to de clarified. We analyzed data from English and French literatures to assess if viremia in asymptomatic dengue infections might be sufficient to represent a true risk. During outbreaks of dengue a large number of individuals are infected and since viremia levels in symptomatic patients are known to vary by many orders of magnitude, it is reasonable to augur that a proportion of asymptomatic cases might reach levels of viremia sufficient to infect competent mosquitoes. In addition, a number of new ways of contamination in man by dengue viruses were recently described such as blood transfusion, bone marrow transplantation, and nosocomial infections that may be worth considering.} }