%A Hoogendijk,Mark %D 2012 %J Frontiers in Physiology %C %F %G English %K Arrhythmogenic right ventricular cardiomyopathy,Brugada Syndrome,desmosome,Sodium channel,Structural heart disease,Sudden cardiac death %Q %R 10.3389/fphys.2012.00144 %W %L %M %P %7 %8 2012-May-23 %9 Review %+ Dr Mark Hoogendijk,St Antonius Ziekenhuis,Department of Cardiology,Nieuwegein,Netherlands,markhoogendijk@hotmail.com %+ Dr Mark Hoogendijk,Academic Medical Center - University of Amsterdam,Experimental Cardiology Group, Heart Failure Research Center,Amsterdam,Netherlands,markhoogendijk@hotmail.com %# %! ARVC and Brugada syndrome %* %< %T Diagnostic Dilemmas: Overlapping Features of Brugada Syndrome and Arrhythmogenic Right Ventricular Cardiomyopathy %U https://www.frontiersin.org/articles/10.3389/fphys.2012.00144 %V 3 %0 JOURNAL ARTICLE %@ 1664-042X %X Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Brugada syndrome are distinct clinical entities which diagnostic criteria exclude their coexistence in individual patients. ARVC is a myocardial disorder characterized by fibro-fatty replacement of the myocardium and ventricular arrhythmias. In contrast, the Brugada syndrome has long been considered a functional cardiac disorder: no gross structural abnormalities can be identified in the majority of patients and its electrocardiographic hallmark of coved-type ST-segment elevation in right precordial leads is dynamic. Nonetheless, a remarkable overlap in clinical features has been demonstrated between these conditions. This review focuses on this overlap and discusses its potential causes and consequences.