AUTHOR=Li Yan-Yan 

TITLE=Lack of Association of ACE2 G8790A Gene Mutation with Essential Hypertension in the Chinese Population: A Meta-Analysis Involving 5260 Subjects

JOURNAL=Frontiers in Physiology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2012.00364

DOI=10.3389/fphys.2012.00364

ISSN=1664-042X

ABSTRACT=<p><bold>Background:</bold> The <italic>angiotensin converting enzyme 2</italic> (<italic>ACE2</italic>) G8790A gene polymorphism has been associated with the susceptibility to essential hypertension (EH), but the results are disputable. <bold>Objective and Methods:</bold> To investigate the relationship between the <italic>ACE2</italic> G8790A gene polymorphism and EH, eight separate studies with 5260 subjects were meta-analyzed. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) were calculated by a random effect model. <bold>Results:</bold> In the <italic>ACE2</italic> G8790A gene polymorphism and EH meta-analysis in a Chinese population, no significant association was found between the <italic>ACE2</italic> G8790A gene polymorphism and EH (OR: 1.03, 95% CI: 0.87–1.21, <italic>P</italic> = 0.76). In the stratified analysis by gender, no significant risk was found among males (OR: 1.06, 95% CI: 0.82–1.36, <italic>P</italic> = 0.66) or females (OR: 0.98, 95% CI: 0.77–1.24, <italic>P</italic> = 0.85). Under a dominant model of inheritance in the female subgroup, the pooled OR for the GG/GA + AA value was 1.01 (95% CI: 0.82–1.25, <italic>P</italic> = 0.92). Under a recessive model of inheritance in the female subgroup, the pooled OR for the AA/AG + GG value was 0.93 (95% CI: 0.50–1.73, <italic>P</italic> = 0.83). <bold>Conclusion:</bold> The current meta-analysis suggested that the <italic>ACE2</italic> G8790A gene polymorphism might not be related to the increased EH risk in the Chinese population.</p>