AUTHOR=Sankaranarayanan Rajiv , Venetucci Luigi TITLE=Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling? JOURNAL=Frontiers in Physiology VOLUME=3 YEAR=2012 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2012.00373 DOI=10.3389/fphys.2012.00373 ISSN=1664-042X ABSTRACT=

Both animal and clinical studies have demonstrated that omega-3 fatty acids have anti-arrhythmic properties. It has been suggested that these anti-arrhythmic effects are due to modulation of the activity of various myocardial calcium handling proteins such as ryanodine receptor (RyR), L-type calcium current and sodium/calcium exchanger. In this article, we review all the data available on the effects of omega-3 fatty acids on ventricular myocardial calcium handling. In addition we highlight some unanswered questions and discuss possible therapeutic benefits of omega-3 fatty acids.