TY - JOUR AU - Queiroz, Thyago AU - Monteiro, Matheus AU - Braga, Valdir PY - 2013 M3 - Review TI - Angiotensin-II-derived reactive oxygen species on baroreflex sensitivity during hypertension: new perspectives JO - Frontiers in Physiology UR - https://www.frontiersin.org/articles/10.3389/fphys.2013.00105 VL - 4 SN - 1664-042X N2 - Hypertension is a multifactorial disorder, which has been associated with the reduction in baroreflex sensitivity (BRS) and autonomic dysfunction. Several studies have revealed that increased reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase, following activation of type 1 receptor (AT1R) by Angiotensin-(Ang) II, the main peptide of the Renin–Angiotensin–Aldosterone System (RAAS), is the central mechanism involved in Ang-II-derived hypertension. In the present review, we will discuss the role of Ang II and oxidative stress in hypertension, the relationship between the BRS and the genesis of hypertension and how the oxidative stress triggers baroreflex dysfunction in several models of hypertension. Finally, we will describe some novel therapeutic drugs for improving the BRS during hypertension. ER -