%A Kurtenbach,Stefan %A Kurtenbach,Sarah %A Zoidl,Georg %D 2014 %J Frontiers in Physiology %C %F %G English %K Gap Junctions,Heart,Connexins,Interactome,signalling,modullation,modification %Q %R 10.3389/fphys.2014.00082 %W %L %M %P %7 %8 2014-February-27 %9 Mini Review %+ Dr Stefan Kurtenbach,York University,Psychology,4700 Keele Street,Toronto,M3J 1P3,Ontario,Canada,stefan.kurtenbach@med.miami.edu %# %! Gap junction modulation and its implications for heart function %* %< %T Gap junction modulation and its implications for heart function %U https://www.frontiersin.org/articles/10.3389/fphys.2014.00082 %V 5 %0 JOURNAL ARTICLE %@ 1664-042X %X Gap junction communication (GJC) mediated by connexins is critical for heart function. To gain insight into the causal relationship of molecular mechanisms of disease pathology, it is important to understand which mechanisms contribute to impairment of gap junctional communication. Here, we present an update on the known modulators of connexins, including various interaction partners, kinases, and signaling cascades. This gap junction network (GJN) can serve as a blueprint for data mining approaches exploring the growing number of publicly available data sets from experimental and clinical studies.