AUTHOR=Lei Ming , Wang Xin , Ke Yunbo , Solaro R. John 

TITLE=Regulation of Ca2+ transient by PP2A in normal and failing heart

JOURNAL=Frontiers in Physiology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2015.00013

DOI=10.3389/fphys.2015.00013

ISSN=1664-042X

ABSTRACT=<p>Calcium transient in cardiomyocytes is regulated by multiple protein kinases and phosphatases. PP2A is a major protein phosphatase in the heart modulating Ca<sup>2+</sup> handling through an array of ion channels, antiporters and pumps, etc. The assembly, localization/translocation, and substrate specificity of PP2A are controlled by different post-translational mechanisms, which in turn are linked to the activities of upstream signaling molecules. Abnormal PP2A expression and activities are associated with defective response to β-adrenergic stimulation and are indication and causal factors in arrhythmia and heart failure.</p>