AUTHOR=Passos Agathoklis D., Mouza Aikaterini A., Paras Spiros V., Gogos Christos , Tziafas Dimitrios TITLE=Designing and testing regenerative pulp treatment strategies: Modeling the transdentinal transport mechanisms JOURNAL=Frontiers in Physiology VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2015.00257 DOI=10.3389/fphys.2015.00257 ISSN=1664-042X ABSTRACT=
The need for simulation models to thoroughly test the inflammatory effects of dental materials and dentinogenic effects of specific signaling molecules has been well recognized in current dental research. The development of a model that simulates the transdentinal flow and the mass transfer mechanisms is of prime importance in terms of achieving the objectives of developing more effective treatment modalities in restorative dentistry. The present protocol study is part of an ongoing investigation on the development of a methodology that can calculate the transport rate of selected molecules inside a typical dentinal tubule. The transport rate of biological molecules has been investigated using a validated