AUTHOR=Li Yan-yan , Wu Jing-jing , Yang Xin-xing , Geng Hong-yu , Gong Ge , Kim Hyun Jun 

TITLE=EPCR Gene Ser219Gly Polymorphism and Venous Thromboembolism: A Meta-Analysis of 9,494 Subjects

JOURNAL=Frontiers in Physiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2017.00339

DOI=10.3389/fphys.2017.00339

ISSN=1664-042X

ABSTRACT=<p><bold>Background:</bold> Although <italic>endothelial cell protein C receptor (EPCR)</italic> gene Ser219Gly polymorphism has been associated with venous thromboembolism (VTE) susceptibility, no clear consensus has yet been reached.</p><p><bold>Objective and methods:</bold> A meta-analysis of 9,494 subjects from 13 individual studies was conducted to better elucidate the potential relationship between the <italic>EPCR</italic> gene Ser219Gly polymorphism and VTE. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed or random effect models.</p><p><bold>Results:</bold> The current meta-analysis suggested that there was a significant association between <italic>EPCR</italic> gene Ser219Gly polymorphism and VTE under allelic (OR: 1.42, 95% CI: 1.21–1.66, <italic>P</italic> = 1.30 × 10<sup>−5</sup>), recessive (OR: 2.02, 95% CI: 1.44–2.85, <italic>P</italic> = 5.35 × 10<sup>−5</sup>), homozygous (OR: 2.24, 95% CI: 1.59–3.16, <italic>P</italic> = 3.66 × 10<sup>−6</sup>), and additive genetic models (OR: 1.63, 95% CI: 1.30–2.04, <italic>P</italic> = 2.24 × 10<sup>−5</sup>).</p><p><bold>Conclusions:</bold><italic>EPCR</italic> gene Ser219Gly polymorphism was associated with an elevated risk of VTE and the Gly residue carriers of the <italic>EPCR</italic> gene might be predisposed to VTE.</p>