AUTHOR=Flôr Atalia F. L. , de Brito Alves José L. , França-Silva Maria S. , Balarini Camille M. , Elias Lucila L. K. , Ruginsk Silvia G. , Antunes-Rodrigues José , Braga Valdir A. , Cruz Josiane C. TITLE=Glial Cells Are Involved in ANG-II-Induced Vasopressin Release and Sodium Intake in Awake Rats JOURNAL=Frontiers in Physiology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00430 DOI=10.3389/fphys.2018.00430 ISSN=1664-042X ABSTRACT=
It is known that circulating angiotensin II (ANG-II) acts on the circumventricular organs (CVOs), which partially lack a normal blood-brain barrier, to stimulate pressor responses, vasopressin (AVP), and oxytocin (OT) secretion, as well as sodium and water intake. Although ANG-II type 1 receptors (AT1R) are expressed in neurons and astrocytes, the involvement of CVOs glial cells in the neuroendocrine, cardiovascular and behavioral responses induced by central ANG II remains to be further elucidated. To address this question, we performed a set of experiments combining