%A Naldi,Aurélien
%A Hernandez,Céline
%A Abou-Jaoudé,Wassim
%A Monteiro,Pedro T.
%A Chaouiya,Claudine
%A Thieffry,Denis
%D 2018
%J Frontiers in Physiology
%C
%F
%G English
%K regulatory network,Logical model,discrete dynamics,regulatory circuit,p53-Mdm2 network.
%Q
%R 10.3389/fphys.2018.00646
%W
%L
%N 646
%M
%P
%7
%8 2018-June-19
%9 Protocols
%#
%! Logical modelling and analysis of cellular regulatory networks with GINsim 3.0.
%*
%<
%T Logical Modeling and Analysis of Cellular Regulatory Networks With GINsim 3.0
%U https://www.frontiersin.org/article/10.3389/fphys.2018.00646
%V 9
%0 JOURNAL ARTICLE
%@ 1664-042X
%X The logical formalism is well adapted to model large cellular networks, in particular when detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative framework. Relying on GINsim (release 3.0), a software implementing this formalism, we guide the reader step by step toward the definition, the analysis and the simulation of a four-node model of the mammalian p53-Mdm2 network.