TY - JOUR AU - Renzini, Alessandra AU - Marroncelli, Nicoletta AU - Noviello, Chiara AU - Moresi, Viviana AU - Adamo, Sergio PY - 2018 M3 - Original Research TI - HDAC4 Regulates Skeletal Muscle Regeneration via Soluble Factors JO - Frontiers in Physiology UR - https://www.frontiersin.org/articles/10.3389/fphys.2018.01387 VL - 9 SN - 1664-042X N2 - Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells. Satellite cell behavior is tightly regulated by the surrounding microenvironment, which provides multiple signals derived from local cells and systemic factors. Among epigenetic mechanisms, histone deacetylation has been proved to affect muscle regeneration. Indeed, pan-histone deacetylase inhibitors were found to improve muscle regeneration, while deletion of histone deacetylase 4 (HDAC4) in satellite cells inhibits their proliferation and differentiation, leading to compromised muscle regeneration. In this study, we delineated the HDAC4 function in adult skeletal muscle, following injury, by using a tissue-specific null mouse line. We showed that HDAC4 is crucial for skeletal muscle regeneration by mediating soluble factors that influence muscle-derived cell proliferation and differentiation. These findings add new biological functions to HDAC4 in skeletal muscle that need considering when administering histone deacetylase inhibitors. ER -