Plasticity of adipose tissue-derived stem cells and angiogenesis regulation
- 1Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F.Voino-Yasenetski, Russia
Adipose tissue is recognized as an important organ with metabolic, regulatory, and plastic roles. Adipose tissue-derived stem cells (ASCs) with self-renewal properties localize in the stromal vascular fraction (SVF) being present in a vascular niche, thereby contributing to local regulation of angiogenesis and vessel remodeling. In last decades, ASCs attract much attention of biologists and bioengineers, particularly, because of their multilineage differentiation potential, strong proliferation and migration abilities in vitro, and high resistance to oxidative stress and senescence. Current data suggest that SVF serves as an important source of endothelial progenitors, endothelial cells, and pericytes, thereby contributing to vessel remodeling and growth. In addition, ASCs demonstrate intriguing metabolic and interlineage plasticity which make them good candidates for creating regenerative therapeutic protocols, in vitro tissue models and microphysiological systems, tissue-on-chip devices for diagnostic and regeneration-supporting purposes. This review covers recent achievements in understanding the metabolic activity within the SVF niches (lactate and NAD+ metabolism) which is critical for maintaining the pool of ASCs, and disclosure of their pro-angiogenic poteintial, particularly, in the complex therapy of cardiovascular and cerebrovascular diseases.
Keywords: Adipose tissue -, Adipocyte, stem cell, endothelial cell, Angiogenesis, vasculature-on-chip
Received: 04 Aug 2018;
Accepted: 02 Nov 2018.
Edited by:Maik Gollasch, Charité Universitätsmedizin Berlin, Germany
Reviewed by:Dmitry Tsvetkov, University of Tubingen, Germany
Yasuhiko Yamamoto, Kanazawa University, Japan
Copyright: © 2018 Panina, Yakimov, Komleva, Morgun, Lopatina, Malinovskaya, Shuvaev, Salmin, Taranushenko and Salmina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Alla B. Salmina, Krasnoyarsk State Medical University named after Prof. V.F.Voino-Yasenetski, Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk, 660022, Russia, firstname.lastname@example.org