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Front. Physiol. | doi: 10.3389/fphys.2019.00777

Effects of a single session of high- and moderate-intensity resistance exercise on endothelial function of middle-aged sedentary men

  • 1Federal University of Rio Grande do Sul, Brazil

Regular resistance exercise is associated with metabolic, neuromuscular and cardiovascular adaptations which improve quality of life and health. However, sedentary subjects have shown acute impairments in endothelial function after high-intensity resistance exercise. The aim of this study was to evaluate endothelial function in sedentary middle-aged men after a single session of resistance exercise at different intensities. Eleven sedentary middle-aged men (40.1±3.9 years; 27.3±1.4 kg/m2) underwent three different conditions of assessment: 1) single knee extension exercise at moderate intensity (MI) [4 sets of 12 repetitions at 50% of one repetition maximal (1RM) for each leg], 2) single knee extension exercise at high intensity (HI) (4 sets of 8 repetitions at 80% of 1RM for each leg), 3) resting for the control condition (CON). Flow-mediated dilation (FMD) was assessed before, 30 and 60 min after exercise. Plasma concentrations of endothelin-1 (ET-1), nitrites and nitrates (NOx) and thiobarbituric acid reactive substances (TBARS) were measured before, immediately after and 60 min after exercise. Blood pressure (BP) was measured prior to the experimental protocols, and in the following times: immediately following, and 2, 5, 10, 15, 30 and 60 min after exertion. There was a significant improvement in FMD 30 min after MI condition (12.5±4.10 vs 17.2±3.9%; p=0.016). NOx levels were significantly higher immediately after MI (6.8±3.3 vs. 12.6±4.2 μM; p=0.007) and there was a significant increase in the concentration of ET-1 immediately after HI (20.02±2.2 vs. 25.4±2.1 pg/mL; p=0.004). However, there was no significant difference for BP (MI vs. HI) and TBARS among the experimental conditions. Resistance exercise performed at moderate intensity improved vasodilatation via increases on NOx levels and FMD in sedentary middle-aged men.

Keywords: Resistance exercise, Flow mediated dilation, Endothelial Function, Nitric Oxide, Endothelin-1

Received: 25 Jun 2018; Accepted: 04 Jun 2019.

Edited by:

Vincent Pialoux, Université Claude Bernard Lyon 1, France

Reviewed by:

Theodore F. Towse, Grand Valley State University, United States
Gregory Brown, University of Nebraska at Kearney, United States
Emily C. Dunford, McMaster University, Canada  

Copyright: © 2019 Boeno, Farinha, Ramis, Macedo, Rodrigues-Krause, Queiroz, Lopez, Pinto and Reischak-Oliveira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: PhD. Alvaro Reischak-Oliveira, Federal University of Rio Grande do Sul, Porto Alegre, Brazil, alvaro.oliveira@ufrgs.br