AUTHOR=Rood Kristiana , Lopez Vanessa , La Frano Michael R. , Fiehn Oliver , Zhang Lubo , Blood Arlin B. , Wilson Sean M. TITLE=Gestational Hypoxia and Programing of Lung Metabolism JOURNAL=Frontiers in Physiology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2019.01453 DOI=10.3389/fphys.2019.01453 ISSN=1664-042X ABSTRACT=

Gestational hypoxia is a risk factor in the development of pulmonary hypertension in the newborn and other sequela, however, the mechanisms associated with the disease remain poorly understood. This review highlights disruption of metabolism by antenatal high altitude hypoxia and the impact this has on pulmonary hypertension in the newborn with discussion of model organisms and human populations. There is particular emphasis on modifications in glucose and lipid metabolism along with alterations in mitochondrial function. Additional focus is placed on increases in oxidative stress and the progression of pulmonary vascular disease in the newborn and on the need for further exploration using a combination of contemporary and classical approaches.