AUTHOR=Hoogendijk Mark G., Géczy Tamás, Yap Sing-Chien, Szili-Torok Tamas TITLE=Pathophysiological Mechanisms of Premature Ventricular Complexes JOURNAL=Frontiers in Physiology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/articles/10.3389/fphys.2020.00406 DOI=10.3389/fphys.2020.00406 ISSN=1664-042X ABSTRACT=Premature ventricular complexes (PVCs) are the most common ventricular arrhythmia. Despite the high prevalence, the cause of PVCs remains elusive in most patients. A better understanding of the underlying pathophysiological mechanism may help to steer future research. This review aims to provide an overview of the potential pathophysiological mechanisms of PVCs and their differentiation.