AUTHOR=Li Jing , Zhang Heng , Dong Yongqiang , Wang Xian , Wang Guang 

TITLE=Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice

JOURNAL=Frontiers in Physiology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.628122

DOI=10.3389/fphys.2021.628122

ISSN=1664-042X

ABSTRACT=The adipose Nod-like receptor protein 3 (NLRP3) inflammasome initiates insulin resistance, but the mechanism of adipose inflammasome activation remains elusive. In this study, Homocysteine (Hcy) is revealed to be participating in insulin resistance via a NLRP3 inflammasome related process. Hcy-induced activation of NLRP3 inflammasomes were observed in adipose while insulin resistance formation in vivo. Give the experimental animal model a high Omega-3 fatty acids diet would change the serum and adipose lipids profile, and may in this is the way Omega-3 fatty acids improve the adipose inflammation and attenuates the insulin resistance.